International network of cancer genome projects Journal Article
| Authors: | Hudson, T. J.; Anderson, W.; Aretz, A.; Barker, A. D.; Bell, C.; Bernabé, R. R.; Bhan, M. K.; Calvo, F.; Eerola, I.; Gerhard, D. S.; Guttmacher, A.; Guyer, M.; Hemsley, F. M.; Jennings, J. L.; Kerr, D.; Klatt, P.; Kolar, P.; Kusuda, J.; Lane, D. P.; Laplace, F.; Lu, Y.; Nettekoven, G.; Ozenberger, B.; Peterson, J.; Rao, T. S.; Remacle, J.; Schafer, A. J.; Shibata, T.; Stratton, M. R.; Vockley, J. G.; Watanabe, K.; Yang, H.; Yuen, M. M. F.; Knoppers, B. M.; Bobrow, M.; Cambon-Thomsen, A.; Dressler, L. G.; Dyke, S. O. M.; Joly, Y.; Kato, K.; Kennedy, K. L.; Nicolás, P.; Parker, M. J.; Rial-Sebbag, E.; Romeo-Casabona, C. M.; Shaw, K. M.; Wallace, S.; Wiesner, G. L.; Zeps, N.; Lichter, P.; Biankin, A. V.; Chabannon, C.; Chin, L.; Clément, B.; Alava, E. D.; Degos, F.; Ferguson, M. L.; Geary, P.; Hayes, D. N.; Johns, A. L.; Kasprzyk, A.; Nakagawa, H.; Penny, R.; Piris, M. A.; Sarin, R.; Scarpa, A.; De Vijver, M. V.; Futreal, P. A.; Aburatani, H.; Bayés, M.; Bowtell, D. D. L.; Campbel, P. J.; Estivill, X.; Grimmond, S. M.; Gut, I.; Hirst, M.; López-Otý́n, C.; Majumder, P.; Marra, M.; McPherson, J. D.; Ning, Z.; Puente, X. S.; Ruan, Y.; Stunnenberg, H. G.; Swerdlow, H.; Velculescu, V. E.; Wilson, R. K.; Xue, H. H.; Yang, L.; Spellman, P. T.; Bader, G. D.; Boutros, P. C.; Flicek, P.; Getz, G.; Guigo, R.; Guo, G.; Haussler, D.; Heath, S.; Hubbard, T. J.; Jiang, T.; Sander, C.; Klimstra, D. |
| Article Title: | International network of cancer genome projects |
| Abstract: | The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | gene mutation; methylation; somatic mutation; gene deletion; mutation; review; neoplasms; metastasis; amino acid substitution; angiogenesis; cancer research; cancer therapy; dna methylation; cancer invasion; cancer genetics; oncogene; methyltransferase; gene rearrangement; epigenetics; genomics; dna mutational analysis; tumor; gene insertion; disease control; tumor gene; transcriptome; genome, human; disease treatment; international cooperation; databases, genetic; genes, neoplasm; genetics, medical; intellectual property |
| Journal Title: | Nature |
| Volume: | 464 |
| Issue: | 7291 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-04-15 |
| Start Page: | 993 |
| End Page: | 998 |
| Language: | English |
| DOI: | 10.1038/nature08987 |
| PUBMED: | 20393554 |
| PROVIDER: | scopus |
| PMCID: | PMC2902243 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 59" - "Export Date: 20 April 2011" - "CODEN: NATUA" - "Source: Scopus" |
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