Molecular classification of breast cancer Journal Article
| Authors: | Provenzano, E.; Ulaner, G. A.; Chin, S. F. |
| Article Title: | Molecular classification of breast cancer |
| Abstract: | Breast cancer is a heterogeneous disease, observed traditionally by morphology and protein expression but, more recently with the advent of modern molecular technologies, at the genomic and transcriptomic level. This review describes the association between the different molecular subtypes with the histologic subtypes of breast cancer alongside some of their major genomic characteristics and illustrates how these subtypes may affect the appearance of tumors on imaging studies. The authors aim to show how molecular stratification can be used to augment traditional methods to improve our understanding of breast cancers and their clinical management. © 2018 Elsevier Inc. |
| Keywords: | signal transduction; overall survival; review; disease free survival; positron emission tomography; follow up; sensitivity and specificity; ki 67 antigen; gene; gene targeting; breast cancer; genes; gene amplification; gene expression profiling; epidermal growth factor receptor 2; genetic association; uvomorulin; tumor suppressor gene; mammography; microarray analysis; genomic instability; breast carcinoma; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; gene dosage; cytokeratin; estrogen receptor; progesterone receptor; adenoid cystic carcinoma; colloid carcinoma; pik3ca gene; fluorodeoxyglucose; mutations; recurrence free survival; pten gene; triple negative breast cancer; germline mutation; lobular carcinoma; molecular classification; copy number alterations; cancer prognosis; erbb2 gene; human epidermal growth factor receptor 2 positive breast cancer; luminal a breast cancer; basal like breast cancer; human; priority journal; cdh1 gene; luminal b breast cancer; breast adenoid cystic carcinoma; breast medullary like carcinoma; breast mucinous carcinoma; breast secretory carcinoma; breast tubular carcinoma; esr1 gene |
| Journal Title: | PET Clinics |
| Volume: | 13 |
| Issue: | 3 |
| ISSN: | 1556-8598 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2018-07-01 |
| Start Page: | 325 |
| End Page: | 338 |
| Language: | English |
| DOI: | 10.1016/j.cpet.2018.02.004 |
| PROVIDER: | scopus |
| PUBMED: | 30100073 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 August 2018 -- Source: Scopus |
