Bladder cancer in cystoscopically normal-appearing mucosa: A case of mistaken identity? Journal Article

  


Authors: Herr, H. W.; Al-Ahmadie, H.; Dalbagni, G.; Reuter, V. E.
Article Title: Bladder cancer in cystoscopically normal-appearing mucosa: A case of mistaken identity?
Abstract: Objective: To test the frequency of malignancy in normal-appearing urothelium in patients with high-risk bladder cancer, as biopsy of normal-appearing mucosa using standard white-light cystoscopy (WLC) reportedly shows carcinoma in situ (CIS) in some patients with bladder tumours. Patients and Methods Cold-cup biopsies of normal-appearing mucosa were obtained by two experienced oncological urologists from 63 patients during transurethral resection of bladder cancers. Each biopsy labelled as normal was interpreted by two expert uropathologists. Results: Each of the biopsies in all 63 patients was interpreted by both urological pathologists as showing normal or benign histology, except that one showed focal CIS. Conclusion S Bladder urothelium appearing normal to expert urological oncologists using standard WLC rarely shows CIS when biopsies are evaluated by experienced uropathologists. © 2010 The Authors. Journal Compilation 2010 BJU International.
Keywords: adult; human tissue; aged; aged, 80 and over; middle aged; major clinical study; histopathology; cancer patient; bladder cancer; urinary bladder neoplasms; biopsy; high risk patient; urothelium; biopsy, needle; carcinoma in situ; epidemiologic methods; urinary bladder; cystoscopy; transurethral resection; bladder carcinoma; mucous membrane; normal; bladder biopsy; bladder mucosa; white light endoscopy
Journal Title: BJU International
Volume: 106
Issue: 10
ISSN: 1464-4096
Publisher: Wiley Blackwell  
Date Published: 2010-11-01
Start Page: 1499
End Page: 1501
Language: English
DOI: 10.1111/j.1464-410X.2010.09332.x
PUBMED: 20346034
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-78349299482&partnerID=40&md5=fcb4c524d98d3a909a148a9dd72a2630
Notes: --- - "Export Date: 20 April 2011" - "CODEN: BJINF" - "Source: Scopus"
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MSK Authors
  1. Guido Dalbagni
    327 Dalbagni
  2. Hikmat Al-Ahmadie
    668 Al-Ahmadie
  3. Victor Reuter
    1234 Reuter
  4. Harry W Herr
    598 Herr
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