Cell-survival probability at large doses: An alternative to the linear-quadratic model Journal Article
| Authors: | Hanin, L. G.; Zaider, M. |
| Article Title: | Cell-survival probability at large doses: An alternative to the linear-quadratic model |
| Abstract: | A model of irradiated cell survival based on rigorous accounting of microdosimetric effects is developed. The model does not assume that the distribution of lesions is Poisson and is applicable to low, intermediate and high acute doses of low or high LET radiation. For small doses, the model produces the linear-quadratic (LQ) model. However, for high doses the bestfitting LQ model grossly underestimates cell survival. The same is also true for the conventional LQ model, only more so. It is shown that for high doses, the microdosimetric distribution can be approximated by a Gaussian distribution, and the corresponding cell survival probabilities are compared. © 2010 Institute of Physics and Engineering in Medicine. |
| Keywords: | radiation dose; methodology; reproducibility; linear models; reproducibility of results; cell survival; biological model; models, biological; algorithms; poisson distribution; algorithm; probability; models, statistical; ionizing radiation; radiation, ionizing; radiometry; statistical model; normal distribution; radiation tolerance |
| Journal Title: | Physics in Medicine and Biology |
| Volume: | 55 |
| Issue: | 16 |
| ISSN: | 0031-9155 |
| Publisher: | IOP Publishing Ltd |
| Date Published: | 2010-08-21 |
| Start Page: | 4687 |
| End Page: | 4702 |
| Language: | English |
| DOI: | 10.1088/0031-9155/55/16/005 |
| PUBMED: | 20671352 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: PHMBA" - "Source: Scopus" |
