An equation for the dose response of radiation-induced apoptosis: Possible incorporation with the LQ model Journal Article

  


Authors: Ling, C. C.; Chen, C. H.; Fuks, Z.
Article Title: An equation for the dose response of radiation-induced apoptosis: Possible incorporation with the LQ model
Abstract: Based on in vitro and in vivo data, we proposed an equation to describe the dose response of radiation-induced apoptosis. This equation can be incorporated into the LQ model to account for the contribution of apoptosis-mediated cell death in clonogenic survival curve. The modified LQ equation is a composite of the dose responses of two subpopulations, one susceptible and the other resistant to apoptotic cell death. For the apoptosis-resistant fraction, the size of which varies for different biological systems, the conventional LQ relation applies. For the susceptible subpopulation, the LQ equation is modified by e-ζD, a functional form consistent with the observed dose-rate independence of this mode of cell death. © 1994.
Keywords: controlled study; dose response; animal; cell death; cell survival; apoptosis; radiation; radiotherapy dosage; algorithms; dose-response relationship, radiation; radiation dosage; models, statistical; ionizing radiation; colony-forming units assay; model; human; priority journal; article; support, u.s. gov't, p.h.s.; linear quadratic equation
Journal Title: Radiotherapy and Oncology
Volume: 33
Issue: 1
ISSN: 0167-8140
Publisher: Elsevier Inc.  
Date Published: 1994-10-01
Start Page: 17
End Page: 22
Language: English
DOI: 10.1016/0167-8140(94)90081-7
PROVIDER: scopus
PUBMED: 7878205
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028114350&doi=10.1016%2f0167-8140%2894%2990081-7&partnerID=40&md5=c5f44f9ed07d0daed95dd361dde76b84
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MSK Authors
  1. Zvi Fuks
    427 Fuks
  2. C Clifton Ling
    331 Ling
  3. Chang Hu Chen
    15 Chen
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