Five-alpha-reductase expression in benign and malignant urothelium: Correlation with disease characteristics and outcome Journal Article
| Authors: | Barocas, D. A.; Kawamoto, H.; Dreizin, D. F.; Howard, M. E.; Choi, J.; Pitts, W. R.; You, X.; Tickoo, S. K.; Boorjian, S. A.; Scherr, D. S. |
| Article Title: | Five-alpha-reductase expression in benign and malignant urothelium: Correlation with disease characteristics and outcome |
| Abstract: | Objectives. To evaluate 5-alpha-reductase (5 alpha R) expression in benign and malignant urothelium and to assess the relationship between 5 alpha R expression and tumor stage, tumor grade, and clinical outcome in patients with urothelial carcinoma/transitional cell carcinoma. Methods. We performed immunohistochemistry for 5 alpha R on 53 urothelial specimens from 36 patients with transitional cell carcinoma treated at our institution between June 2002 and July 2003. For each tumor and the adjacent nontumor urothelium, a semiquantitative staining score was calculated. We used t tests and analysis of variance to compare the staining score across groups. Kaplan-Meier and logistic regression analyses were performed to assess the relationship between 5 alpha R expression and clinical outcome. Results. 5aR was expressed throughout the non-neoplastic urothelium. Nontumor urothelium had greater mean staining scores than did tumor specimens (160.1 versus 105.5, P <0.0 1). Low staining scores were associated with high grade (P <0.05), Stage pT3, pT4, and pTis (P <0.05), and disease progression (P <0.05). A staining score less than the median was a risk factor for progression (odds ratio 6.2, P <0.0 1) on univariate regression analysis. Patients with a staining score less than the median had a greater likelihood of disease progression (log-rank P <0.05) and cause-specific mortality (log-rank P <0.05). Conclusions. We demonstrated 5 alpha R expression in human urothelium and found that expression is decreased in transitional cell carcinoma in relation to tumor grade and stage. Decreased 5 alpha R expression was associated with disease progression and cause-specific mortality. |
| Keywords: | androgen; carcinogenesis; tumors; carcinoma; rats; human tissues; localization; urinary-bladder |
| Journal Title: | Urology |
| Volume: | 66 |
| Issue: | 5 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2005-11-01 |
| Start Page: | 1134 |
| End Page: | 1139 |
| Language: | English |
| DOI: | 10.1016/j.urology.2005.06.079 |
| ACCESSION: | WOS:000233934100059 |
| PROVIDER: | wos |
| PUBMED: | 16286153 |
| Notes: | --- - Article - "Source: Wos" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work