Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo Journal Article
| Authors: | Larson, B.; Abeytunge, S.; Rajadhyaksha, M. |
| Article Title: | Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo |
| Abstract: | Point-scanning reflectance confocal microscopes continue to be successfully translated for detection of skin cancer. Line-scanning, with the use of a single scanner and a linear-array detector, offers a potentially smaller, simpler and lower cost alternative approach, to accelerate widespread dissemination into the clinic. However, translation will require an understanding of imaging performance deep within scattering and aberrating human tissues. We report the results of an investigation of the performance of a full-pupil line-scanning reflectance confocal microscope in human skin and oral mucosa, in terms of resolution, optical sectioning, contrast, signal-to-noise ratio, imaging and the effect of speckle noise. © 2011 Optical Society of America. |
| Keywords: | linescanning; scanning; confocal microscopy; in-vivo; confocal microscopes; human skin; human tissues; reflectance confocal microscopies; reflection; optical sectioning; skin cancers; tissue; oral mucosa; linear-array; imaging performance; alternative approach; speckle noise |
| Journal Title: | Biomedical Optics Express |
| Volume: | 2 |
| Issue: | 7 |
| ISSN: | 2156-7085 |
| Publisher: | Optical Society of America |
| Date Published: | 2011-07-01 |
| Start Page: | 2055 |
| End Page: | 2067 |
| Language: | English |
| DOI: | 10.1364/boe.2.002055 |
| PROVIDER: | scopus |
| PMCID: | PMC3130589 |
| PUBMED: | 21750780 |
| DOI/URL: | |
| Notes: | --- - Cited By (since 1996):3 - "Export Date: 21 May 2013" - "Source: Scopus" |
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32Abeytunge
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