The public health utility of genome-wide association study results for smoking behavior Journal Article
| Authors: | Furberg, H.; Ostroff, J.; Lerman, C.; Sullivan, P. F. |
| Article Title: | The public health utility of genome-wide association study results for smoking behavior |
| Abstract: | New approaches to improve smoking cessation rates are needed. In recent years, substantial progress has been made in understanding the genetics of smoking behavior, and this knowledge may eventually be used to personalize treatment for smokers. Although there are highly significant and reproducible genetic associations, none are yet ready for clinical applications. We suggest that translational research from several disciplines, including behavioral science, ethics and economics, should be performed in parallel with ongoing genome-wide association studies for smoking behavior and pharmacogenetic trials. The coordinated effort of multidisciplinary research teams will help reveal the circumstances under which we can translate genetic insights into clinical practice in the hope of reducing the burden of smoking in society. © 2010 BioMed Central Ltd. |
| Keywords: | note; clinical practice; genetic association; smoking cessation; smoking; health care utilization; economics; gene interaction; pharmacogenetics; ethics; translational research; amfebutamone; varenicline; behavioral science; environmental impact; nicotine replacement therapy |
| Journal Title: | Genome Medicine |
| Volume: | 2 |
| Issue: | 4 |
| ISSN: | 1756-994X |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2010-04-27 |
| Start Page: | 26 |
| Language: | English |
| DOI: | 10.1186/gm147 |
| PROVIDER: | scopus |
| PMCID: | PMC2873804 |
| PUBMED: | 20423533 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Art. No.: 26" - "Source: Scopus" |
