| Authors: |
David, S. P.; Hamidovic, A.; Chen, G. K.; Bergen, A. W.; Wessel, J.; Kasberger, J. L.; Brown, W. M.; Petruzella, S.; Thacker, E. L.; Kim, Y.; Nalls, M. A.; Tranah, G. J.; Sung, Y. J.; Ambrosone, C. B.; Arnett, D.; Bandera, E. V.; Becker, D. M.; Becker, L.; Berndt, S. I.; Bernstein, L.; Blot, W. J.; Broeckel, U.; Buxbaum, S. G.; Caporaso, N.; Casey, G.; Chanock, S. J.; Deming, S. L.; Diver, W. R.; Eaton, C. B.; Evans, D. S.; Evans, M. K.; Fornage, M.; Franceschini, N.; Harris, T. B.; Henderson, B. E.; Hernandez, D. G.; Hitsman, B.; Hu, J. J.; Hunt, S. C.; Ingles, S. A.; John, E. M.; Kittles, R.; Kolb, S.; Kolonel, L. N.; Le Marchand, L.; Liu, Y.; Lohman, K. K.; McKnight, B.; Millikan, R. C.; Murphy, A.; Neslund-Dudas, C.; Nyante, S.; Press, M.; Psaty, B. M.; Rao, D. C.; Redline, S.; Rodriguez-Gil, J. L.; Rybicki, B. A.; Signorello, L. B.; Singleton, A. B.; Smoller, J.; Snively, B.; Spring, B.; Stanford, J. L.; Strom, S. S.; Swan, G. E.; Taylor, K. D.; Thun, M. J.; Wilson, A. F.; Witte, J. S.; Yamamura, Y.; Yanek, L. R.; Yu, K.; Zheng, W.; Ziegler, R. G.; Zonderman, A. B.; Jorgenson, E.; Haiman, C. A.; Furberg, H. |
| Article Title: |
Genome-wide meta-analyses of smoking behaviors in African Americans |
| Abstract: |
The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527A) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (Β=0.040, s.e.=0.007, P=1.84 × 10 -8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans. © 2012 Macmillan Publishers Limited All rights reserved. |
| Keywords: |
adult; aged; middle aged; single nucleotide polymorphism; genetics; polymorphism, single nucleotide; cigarette smoking; phenotype; genetic predisposition to disease; statistics; nerve tissue proteins; gene locus; genetic association; genetic variability; genotype; gene frequency; genetic variation; genome-wide association study; smoking cessation; smoking; 5' untranslated region; genetic susceptibility; statistics as topic; genetic predisposition; african americans; nerve protein; meta analysis; african american; chromosome 15q; chromosomes, human, pair 15; chromosome 10; nicotinic receptor; effect size; genetic loci; gene linkage disequilibrium; proteoglycans; proteoglycan; chromosome 15; receptors, nicotinic; chromosomes, human, pair 10; chrna5 protein, human; spock2 protein, human
|
| Journal Title: |
Translational Psychiatry
|
| Volume: |
2 |
| ISSN: |
2158-3188 |
| Publisher: |
Macmillan Publishers Limited
|
| Date Published: |
2012-01-01 |
| Start Page: |
e119 |
| Language: |
English |
| DOI: |
10.1038/tp.2012.41
|
| PROVIDER: |
scopus
|
| PUBMED: |
22832964
|
| PMCID: |
PMC3365260
|
| DOI/URL: |
|
| Notes: |
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- "Export Date: 4 June 2012"
- "Source: Scopus"
|
