Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel Journal Article
| Authors: | Wojtovich, A. P.; Smith, C. O.; Haynes, C. M.; Nehrke, K. W.; Brookes, P. S. |
| Article Title: | Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel |
| Abstract: | In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K+ (mKATP) channel. This review will address the involvement of complex II in each of these areas, with a focus on how complex II regulates or may be involved in the assembly of the mKATP. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease. |
| Keywords: | ischemia; succinate dehydrogenase; diazoxide; atp sensitive potassium channel; mkatp; preconditioning |
| Journal Title: | Biochimica et Biophysica Acta (BBA) - Bioenergetics |
| Volume: | 1827 |
| Issue: | 5 |
| ISSN: | 0005-2728 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2013-05-01 |
| Start Page: | 598 |
| End Page: | 611 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 23291191 |
| DOI: | 10.1016/j.bbabio.2012.12.007 |
| PMCID: | PMC3880126 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2013" - "CODEN: BBBEB" - ":doi 10.1016/j.bbabio.2012.12.007" - "Source: Scopus" |
