Ki-67 is a prognostic biomarker of survival after radiofrequency ablation of liver malignancies Journal Article


Authors: Sofocleous, C. T.; Garg, S.; Petrovic, L. M.; Gonen, M.; Petre, E. N.; Klimstra, D. S.; Solomon, S. B.; Brown, K. T.; Brody, L. A.; Covey, A. M.; DeMatteo, R. P.; Schwartz, L.; Kemeny, N. E.
Article Title: Ki-67 is a prognostic biomarker of survival after radiofrequency ablation of liver malignancies
Abstract: Purpose. To assess the predictive value of examinations of tissue adherent to multitined electrodes on local tumor progression-free survival (LPFS) and overall survival (OS) after liver tumor radiofrequency ablation (RFA). Methods. An institutional review board-approved, Health Insurance Portability and Accountability Act-compliant review identified 68 liver tumors treated with RFA in 63 patients with at least 3 years' follow-up. Tissue adherent to the electrode after liver tumor RFA was evaluated with proliferation (Ki-67) and apoptotic (caspase-3) markers. LPFS and OS were evaluated by Kaplan-Meier methodology and the log-rank test. Multivariate analysis assessed the effect of tumor size, pathology, and post-RFA tissue characteristics on LPFS and OS. Results. Post-RFA tissue examination classified 55 of the 68 tumors as completely ablated with coagulation necrosis, with cells positive for caspase-3 and negative for Ki-67 (CN). Thirteen had viable Ki-67-positive tumor cells. Mean liver tumor size was larger in the viable (V) group versus the CN group (3.4 vs. 2.5 cm, respectively; P = .017). For the V and CN groups, respectively, local tumor progression occurred in 12 (92 %) of 13 and 23 (42 %) of 55 specimens. One, 3-, and 5-year LPFS was 8 %, 8 %, and 8 %, and 79 %, 47 %, and 47 % (P<.001) for the V and CN groups, respectively. During a 63-month median follow-up, 92 % of patients in the V group and 58 % in the CN group died, resulting in 1-, 3-, and 5-year OS of 92 %, 25 %, and 8 % vs. 92 %, 59 %, and 33 % (P = .032), respectively. Conclusions. Ki-67-positive tumor cells on the electrode after liver tumor RFA is an independent predictor of LPFS and OS. Size, initially thought to be an independent risk factor for local tumor progression in tumors 3-5 cm, does not hold its significance at long follow-up. © 2012 Society of Surgical Oncology.
Journal Title: Annals of Surgical Oncology
Volume: 19
Issue: 13
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2012-12-01
Start Page: 4262
End Page: 4269
Language: English
PROVIDER: scopus
PUBMED: 22752375
DOI: 10.1245/s10434-012-2461-9
PMCID: PMC4122119
DOI/URL:
Notes: --- - Cited By (since 1996):1 - "Export Date: 1 May 2013" - "CODEN: ASONF" - ":doi 10.1245/s10434-012-2461-9" - "Source: Scopus"
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MSK Authors
  1. Ronald P DeMatteo
    627 DeMatteo
  2. Mithat Gonen
    778 Gonen
  3. Lawrence H Schwartz
    282 Schwartz
  4. Anne Covey
    133 Covey
  5. David S Klimstra
    912 Klimstra
  6. Lynn Brody
    100 Brody
  7. Karen T Brown
    171 Brown
  8. Stephen Solomon
    302 Solomon
  9. Elena Nadia Petre
    58 Petre
  10. Nancy Kemeny
    434 Kemeny
  11. Sandeep Kumar Garg
    2 Garg