Transitions between epithelial and mesenchymal states and the morphogenesis of the early mouse embryo Journal Article

   

Authors:	Ferrer-Vaquer, A.; Viotti, M.; Hadjantonakis, A. K.
Article Title:	Transitions between epithelial and mesenchymal states and the morphogenesis of the early mouse embryo
Abstract:	Multicellular organisms arise from the generation of different cell types and the organization of cells into tissues and organs. Cells of metazoa display two main phenotypes, the ancestral epithelial state and the recent mesenchymal derivative. Eepithelial cells are usually stationary and reside in two-dimensional sheets. By contrast mesenchymal cells are loosely packed and can move to new positions, thereby providing a vehicle for cell rearrangement, dispersal and novel cell-cell interactions. Transitions between epithelial and mesenchymal states drive key morphogenetic events in the early vertebrate embryo, including gastrulation, germ layer formation and somitogenesis. The cell behaviors and molecular mechanisms promoting transitions between these two states in the early mouse embryo are discussed in this review. © 2010 Landes Bioscience.
Keywords:	review; nonhuman; mesenchyme cell; embryo development; morphogenesis; vertebrata; epithelium cell; epithelization; mesoderm; endoderm; mouse embryo; emt; metazoa; gastrulation; met; epiblast; primitive streak; paraxial mesoderm; somitogenesis; epithelial mesenchymal transition; germ layer
Journal Title:	Cell Adhesion & Migration
Volume:	4
Issue:	3
ISSN:	1933-6918
Publisher:	Landes Bioscience
Date Published:	2010-07-01
Start Page:	440
End Page:	450
Language:	English
DOI:	10.4161/cam.4.3.12000
PROVIDER:	scopus
PMCID:	PMC2958623
PUBMED:	20200481
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77956476869&partnerID=40&md5=e8c8c3beb332a97dd769d1672085163c
Notes:	--- - "Export Date: 20 April 2011" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/4059