Interpreting the Epstein-Barr virus (EBV) epigenome using high-throughput data Journal Article


Authors: Arvey, A.; Tempera, I.; Lieberman, P. M.
Article Title: Interpreting the Epstein-Barr virus (EBV) epigenome using high-throughput data
Abstract: The Epstein-Barr virus (EBV) double-stranded DNA genome is subject to extensive epigenetic regulation. Large consortiums and individual labs have generated a vast number of genome-wide data sets on human lymphoblastoid and other cell lines latently infected with EBV. Analysis of these data sets reveals important new information on the properties of the host and viral chromosome structure organization and epigenetic modifications. We discuss the mapping of these data sets and the subsequent insights into the chromatin structure and transcription factor binding patterns on latent EBV genomes. Colocalization of multiple histone modifications and transcription factors at regulatory loci are considered in the context of the biology and regulation of EBV. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
Keywords: unclassified drug; nonhuman; note; dna replication; genetic analysis; cohesin; transcription factor; dna methylation; gene expression regulation; gene mapping; epigenetics; chromatin; chromatin immunoprecipitation; epigenesis, genetic; nucleotide sequence; transcription factor sp1; binding site; virus genome; epstein barr virus; herpesvirus 4, human; heterochromatin; chromatin structure; human herpesvirus 4; histone modification; genome, viral; epigenomics; micrococcal nuclease; protein c fos; transcription factor pu 1; transcription factor elf 1; deoxyribonuclease i; epstein-barr virus; high throughput sequencing; ctcf; transcription factor ctcf; gammaherpesvirus; orip; ebf protein; micrococcal nuclease i; octamer transcription factor 2; pbx3 protein; protein bcl 3; rxra protein; tcf12 protein; transcription factor jund; transcription factor yy1; znf143 protein; origin of latent replication
Journal Title: Viruses
Volume: 5
Issue: 4
ISSN: 1999-4915
Publisher: MDPI  
Date Published: 2013-04-02
Start Page: 1042
End Page: 1054
Language: English
PROVIDER: scopus
PUBMED: 23549386
DOI: 10.3390/v5041042
PMCID: PMC3705264
DOI/URL:
Notes: --- - "Export Date: 1 May 2013" - ":doi 10.3390/v5041042" - "Source: Scopus"
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  1. Aaron J. Arvey
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