Covalent histone modifications-miswritten, misinterpreted and mis-erased in human cancers Journal Article
| Authors: | Chi, P.; Allis, C. D.; Wang, G. G. |
| Article Title: | Covalent histone modifications-miswritten, misinterpreted and mis-erased in human cancers |
| Abstract: | Post-translational modification of histones provides an important regulatory platform for processes such as gene transcription and DNA damage repair. It has become increasingly apparent that the misregulation of histone modification, which is caused by the deregulation of factors that mediate the modification installation, removal and/or interpretation, actively contributes to human cancer. In this Review, we summarize recent advances in understanding the interpretation of certain histone methylations by plant homeodomain finger-containing proteins, and how misreading, miswriting and mis-erasing of histone methylation marks can be associated with oncogenesis and progression. These observations provide us with a greater mechanistic understanding of epigenetic alterations in human cancers and might also help direct new therapeutic interventions in the future. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | methylation; somatic mutation; gene deletion; review; cancer growth; nonhuman; neoplasms; animals; dna repair; gene overexpression; genetic transcription; carcinogenesis; gene rearrangement; regulatory mechanism; protein processing, post-translational; epigenetics; histone; homeodomain protein; histones; protein modification |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 10 |
| Issue: | 7 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-07-01 |
| Start Page: | 457 |
| End Page: | 469 |
| Language: | English |
| DOI: | 10.1038/nrc2876 |
| PUBMED: | 20574448 |
| PROVIDER: | scopus |
| PMCID: | PMC3262678 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 20 April 2011" - "CODEN: NRCAC" - "Source: Scopus" |
