Activating mutations in HER2: Neu opportunities and Neu challenges Journal Article
| Authors: | Weigelt, B.; Reis-Filho, J. S. |
| Article Title: | Activating mutations in HER2: Neu opportunities and Neu challenges |
| Abstract: | Twenty-fi ve years after the publication of seminal studies showing that HER2 gene amplifi cation and protein overexpression are oncogenic in breast cancer, Bose and colleagues report on the identifi cation of activating HER2 somatic mutations that, albeit rare, may determine the response of breast cancer cells to anti-HER2 agents. These results herald a new era for the potential use of existing HER2-targeted agents for the treatment of patients with H£R2 -mutant breast cancer. © 2012 American Association for Cancer Research. |
| Journal Title: | Cancer Discovery |
| Volume: | 3 |
| Issue: | 2 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2013-02-01 |
| Start Page: | 145 |
| End Page: | 147 |
| Language: | English |
| DOI: | 10.1158/2159-8290.cd-12-0585 |
| PROVIDER: | scopus |
| PUBMED: | 23400474 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2013" - "Source: Scopus" |
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