Collision in the inferior olive: Hypertrophic olivary degeneration complicated by radiation necrosis in brainstem primitive neuroendocrine tumor Journal Article


Authors: Litkowski, P.; Young, R. J.; Wolden, S. L.; Souweidane, M. M.; Haque, S.; Gilheeney, S. W.
Article Title: Collision in the inferior olive: Hypertrophic olivary degeneration complicated by radiation necrosis in brainstem primitive neuroendocrine tumor
Abstract: Hypertrophic olivary degeneration (HOD) is caused by disruption of the triangle of Guillain and Mollaret. We describe a child with a primitive neuroendocrine tumor who developed an expansile nonenhancing lesion in the olive after surgery and radiation therapy. Diffusion tensor imaging and tractography showed disruption of the central tegmental tract consistent with HOD. Subsequent transient enhancement of the olive was consistent with early radiation injury. Knowledge of coexisting complications such as HOD and radiation injury is essential for proper management. © 2012 Elsevier Inc.
Keywords: cancer chemotherapy; child; preschool child; treatment outcome; child, preschool; case report; cisplatin; cancer radiotherapy; radiation dose; neuroimaging; nuclear magnetic resonance imaging; follow-up studies; magnetic resonance imaging; carboplatin; cyclophosphamide; vincristine; radiation injury; necrosis; high risk patient; time factors; risk assessment; neuroendocrine tumor; image enhancement; tumors; radiotherapy, intensity-modulated; radiation injuries; external beam radiotherapy; brain stem neoplasms; radiation necrosis; nerve cell degeneration; neuroendocrine tumors; nerve degeneration; diffusion tensor imaging; hypertrophy; brainstem; monitoring, physiologic; fractional anisotropy; tractography; hypertrophic olivary degeneration; primitive neuroendocrine tumor; tensors; olivary nucleus
Journal Title: Clinical Imaging
Volume: 36
Issue: 4
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2012-07-01
Start Page: 371
End Page: 374
Language: English
DOI: 10.1016/j.clinimag.2011.09.014
PUBMED: 22726977
PROVIDER: scopus
PMCID: PMC4728139
DOI/URL:
Notes: --- - "Export Date: 4 February 2013" - "CODEN: CLIME" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Robert J Young
    108 Young
  2. Suzanne L Wolden
    419 Wolden
  3. Sofia S Haque
    72 Haque