MRI perfusion in determining pseudoprogression in patients with glioblastoma Journal Article


Authors: Young, R. J.; Gupta, A.; Shah, A. D.; Graber, J. J.; Chan, T. A.; Zhang, Z.; Shi, W.; Beal, K.; Omuro, A. M.
Article Title: MRI perfusion in determining pseudoprogression in patients with glioblastoma
Abstract: We examine the role of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion in differentiating pseudoprogression from progression in 20 consecutive patients with treated glioblastoma. MRI perfusion was performed, and relative cerebral blood volume (rCBV), relative peak height (rPH), and percent signal recovery (PSR) were measured. Pseudoprogression demonstrated lower median rCBV (P=009) and rPH (P<.001), and higher PSR (P=039) than progression. DSC MRI perfusion successfully identified pseudoprogression in patients who did not require a change in treatment despite radiographic worsening following chemoradiotherapy. © 2013 Elsevier Inc.
Keywords: glioblastoma; progression; pseudoprogression; mri perfusion
Journal Title: Clinical Imaging
Volume: 37
Issue: 1
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2013-01-01
Start Page: 41
End Page: 49
Language: English
DOI: 10.1016/j.clinimag.2012.02.016
PROVIDER: scopus
PUBMED: 23151413
PMCID: PMC4755513
DOI/URL:
Notes: --- - "Export Date: 1 February 2013" - "CODEN: CLIME" - "Source: Scopus"
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MSK Authors
  1. Zhigang Zhang
    240 Zhang
  2. Timothy Chan
    215 Chan
  3. Weiji Shi
    111 Shi
  4. Robert J Young
    108 Young
  5. Antonio Marcilio Padula Omuro
    176 Omuro
  6. Kathryn Beal
    157 Beal
  7. Jerome Jeffrey Graber
    24 Graber
  8. Akash Deelip Shah
    8 Shah
  9. Ajay Gupta
    6 Gupta