Intravenous bisphosphonate-related osteonecrosis of the jaw: Long-term follow-up of 109 patients Journal Article


Authors: Watters, A. L.; Hansen, H. J.; Williams, T.; Chou, J. F.; Riedel, E.; Halpern, J.; Tunick, S.; Bohle, G.; Huryn, J. M.; Estilo, C. L.
Article Title: Intravenous bisphosphonate-related osteonecrosis of the jaw: Long-term follow-up of 109 patients
Abstract: Objective: We report long-term follow-up of patients with intravenous bisphosphonate-related osteonecrosis of the jaw (BRONJ). Study Design: Medical and dental histories, including type and duration of bisphosphonate treatment and comorbidities, were analyzed and compared with clinical course of 109 patients with BRONJ at Memorial Sloan-Kettering Cancer Center Dental Service. Results: Median onset of BRONJ in months was 21 (zoledronic acid), 30 (pamidronate), and 36 (pamidronate plus zoledronic acid), with a significant difference between the pamidronate plus zoledronic acid and zoledronic acid groups (P =.01; Kruskal-Wallis). The median number of doses for BRONJ onset was significantly less with zoledronic acid (n = 18) than pamidronte plus zoledronic acid (n = 36; P =.001), but not pamidronate alone (n = 29). An association between diabetes (P =.05), decayed-missing-filled teeth (P =.02), and smoking (P =.03) and progression of BRONJ was identified through χ2 test. Conclusions: This long-term follow-up of BRONJ cases enhances the literature and contributes to the knowledge of BRONJ clinical course. © 2013 Elsevier Inc.
Journal Title: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume: 115
Issue: 2
ISSN: 2212-4403
Publisher: Elsevier B.V.  
Date Published: 2013-02-01
Start Page: 192
End Page: 200
Language: English
DOI: 10.1016/j.oooo.2012.05.017
PROVIDER: scopus
PUBMED: 23036797
DOI/URL:
Notes: --- - "Export Date: 1 February 2013" - "Source: Scopus"
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MSK Authors
  1. Joanne Fu-Lou Chou
    157 Chou
  2. Joseph M Huryn
    71 Huryn
  3. Jerry L Halpern
    11 Halpern
  4. Steven J Tunick
    8 Tunick
  5. George C Bohle
    17 Bohle
  6. Cherry Estilo
    65 Estilo
  7. Heidi Jes Hansen
    3 Hansen