Medication-related osteonecrosis of the jaw: An update on the Memorial Sloan Kettering Cancer Center experience and the role of premedication dental evaluation in prevention Journal Article
| Authors: | Owosho, A. A.; Liang, S. T. Y.; Sax, A. Z.; Wu, K.; Yom, S. K.; Huryn, J. M.; Estilo, C. L. |
| Article Title: | Medication-related osteonecrosis of the jaw: An update on the Memorial Sloan Kettering Cancer Center experience and the role of premedication dental evaluation in prevention |
| Abstract: | Objective: The aim of this study was to investigate the relationship between type of antiresorptive medication and medication-related osteonecrosis of the jaw (MRONJ) onset and the role of premedication dental evaluation (PMDE) in the prevention of MRONJ. Study Design: Our database of patients with MRONJ was reviewed. The Kruskal-Wallis test was used to analyze the onset dose of the 3 frequent medication types associated with MRONJ. To evaluate the role of PMDE in the prevention of MRONJ, all patients on antiresorptive and/or antiangiogenic medications seen in the Dental Service of Memorial Sloan Kettering Cancer Center during a 10-year period were subclassified into 2 groups. Group I comprised patients seen for PMDE before the commencement of A/A and group II patients seen after prior exposure to antiresorptive and/or antiangiogenic medications. Fischer's exact test was used to compare the incidence of MRONJ in both groups. Results: Patients on denosumab developed MRONJ earlier compared with zoledronate and pamidronate (P =.003). Group I had a significantly reduced incidence of MRONJ (0.9%) compared with group II (10.5%) (P <.0001). Dentoalveolar trauma as a precipitating factor between groups I and II was not statistically significant. Conclusions: Denosumab was associated with an earlier occurrence of MRONJ compared with zoledronate and pamidronate. The role of PMDE may be an effective preventive strategy in reducing the incidence of MRONJ. © 2018 Elsevier Inc. |
| Journal Title: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| Volume: | 125 |
| Issue: | 5 |
| ISSN: | 2212-4403 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2018-05-01 |
| Start Page: | 440 |
| End Page: | 445 |
| Language: | English |
| DOI: | 10.1016/j.oooo.2018.02.003 |
| PROVIDER: | scopus |
| PUBMED: | 29580668 |
| PMCID: | PMC7518027 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2018 -- Source: Scopus |
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