Focal therapy of localised prostate cancer by vascular targeted photodynamic therapy with WST-11 (TOOKAD® Soluble) Journal Article

  


Authors: Coleman, J.; Scherz, A.
Article Title: Focal therapy of localised prostate cancer by vascular targeted photodynamic therapy with WST-11 (TOOKAD® Soluble)
Abstract: Photodynamic therapy (PDT) is the activation of a light sensitive compound within tissues to produce a desired treatment effect, including apoptosis and necrosis, and is a modality effectively used in a variety of benign and malignant conditions for the purpose of tissue ablation. TOOKAD® (T or WST-09) and TOOKAD Soluble (TS or WST-11), two derivatives of the photosynthetic pigment bacteriochlorophyll (Bchl), represent a new generation of photosensitizers and a new paradigm in PDT for cancer treatment. Studies of the mechanism of action, optimisation of treatment parameters, and therapeutic efficacy have included rigorous laboratory research, preclinical models and a series of prospectively designed clinical investigations demonstrating the great promise for this class of therapeutics in the treatment of human malignancies. This short review briefly describes the principles of T/TS vascular targeted photodynamic therapy and its application in the context of localised prostate cancer treatment as a form of focal therapy. © Touch Medical Media 2012.
Keywords: prostate cancer; prostate; reactive oxygen species; photodynamic therapy; focal therapy; reactive nitrogen species; tookad®
Journal Title: European Urological Review
Volume: 7
Issue: 2
ISSN: 1758-3829
Publisher: Touch Medical Media  
Date Published: 2012-01-01
Start Page: 106
End Page: 108
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84871835498&partnerID=40&md5=9a6837ec08b124c3d5813d1537dfa051
Notes: --- - "Export Date: 1 February 2013" - "Source: Scopus"