Developments in vascular-targeted photodynamic therapy for urologic malignancies Review


Authors: Nogueira, L.; Tracey, A. T.; Alvim, R.; Reisz, P.; Scherz, A.; Coleman, J. A.; Kim, K.
Review Title: Developments in vascular-targeted photodynamic therapy for urologic malignancies
Abstract: With improved understanding of cancer biology and technical advancements in non-invasive management of urological malignancies, there is renewed interest in photodynamic therapy (PDT) as a means of focal cancer treatment. The application of PDT has also broadened as a result of development of better-tolerated and more effective photosensitizers. Vascular-targeted PDT (VTP) using padeliporfin, which is a water-soluble chlorophyll derivative, allows for tumor-specific cytotoxicity and has demonstrated efficacy in the management of urologic malignancies. Herein, we describe the evolution of photodynamic therapy in urologic oncology and the role of VTP in emerging treatment paradigms.
Keywords: prostate cancer; urothelial cancer; vascular-targeted photodynamic therapy
Journal Title: Molecules
Volume: 25
Issue: 22
ISSN: 1420-3049
Publisher: MDPI  
Date Published: 2020-11-01
Start Page: 5417
Language: English
DOI: 10.3390/molecules25225417
PUBMED: 33228126
PROVIDER: scopus
PMCID: PMC7699359
DOI/URL:
Notes: Review -- Export Date: 4 January 2021 -- Source: Scopus
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MSK Authors
  1. Jonathan Coleman
    344 Coleman
  2. Kwanghee   Kim
    43 Kim
  3. Ricardo Goncalves Alvim
    25 Alvim
  4. Andrew Thomas Tracey
    13 Tracey
  5. Peter Anselm Reisz
    17 Reisz