Synapse - Cancer-related infertility in survivorship

Cancer-related infertility in survivorship Journal Article

Authors:	Carter, J.; Chi, D. S.; Brown, C. L.; Abu-Rustum, N. R.; Sonoda, Y.; Aghajanian, C.; Levine, D. A.; Baser, R. E.; Raviv, L.; Barakat, R. R.
Article Title:	Cancer-related infertility in survivorship
Abstract:	Introduction: To empirically assess and describe the emotional, sexual, and physical impact of cancer-related infertility on gynecologic cancer survivors Methods: The study was composed of 88 survivors of cervical, endometrial/uterine, ovarian cancer, and gestational trophoblastic disease who experienced impaired or loss of fertility as a result of treatment Patient age ranged from 21 to 49 years Participants completed a 1-time self-report survey, including medical and demographic information and empirical measures of mood (Center for Epidemiologic Studies Depression Scale), distress (Impact of Event Scale), sexual function (Female Sexual Function Index), and menopause (Menopausal Symptom Checklist) Results: Eighty-four (96%) of the 88 enrolled patients had undergone a surgical intervention as part of their cancer treatment Sixty-three patients (77%) reported clinically significant levels of distress in relation to loss of fertility or impaired fertility Survivors' levels of distress (P < 0.0001) and depression (P < 0.0001) were associated with the severity and number of menopausal symptoms reported Patients who retained functioning ovaries (partial fertility) (41%, n = 36) reported being less bothered by menopausal symptoms (P = 0.01) and having higher sexual functioning than those with ovarian failure (P < 0.0001) Conclusions: The emotional and physical impact of impaired or loss of fertility can be complex and long lasting, with women experiencing high levels of distress, menopausal symptoms, and changes in sexual function persisting into survivorship Future research should focus on the development of strategies to identify, monitor, and address, in a clinical care setting, the issues these cancer survivors face Alternate family-building strategies should also be explored before treatment and/or upon treatment completion when feasible. Copyright © 2010 by IGCS and ESGO.
Keywords:	adult; controlled study; middle aged; cancer surgery; young adult; major clinical study; review; antineoplastic agent; endometrium cancer; monitoring; demography; ovary cancer; breast neoplasms; infertility; ovary insufficiency; cancer survivor; survivors; genital neoplasms, female; ovary; intervention study; depression; mood; disease severity; feasibility study; medical information; uterine cervix cancer; carcinoma; survivorship; clinical research; distress syndrome; rating scale; emotion; menopause; alprazolam; venlafaxine; uterus cancer; gynecologic cancer; atenolol; atorvastatin; testosterone; sexual function; citalopram; clonazepam; paroxetine; oral contraceptive agent; alendronic acid; infertility, female; sexual behavior; trophoblastic tumor; menopausal syndrome; diltiazem; estradiol plus norethisterone acetate; levothyroxine sodium; progesterone; center for epidemiological studies depression scale; family planning; impact of events scale
Journal Title:	International Journal of Gynecological Cancer
Volume:	20
Issue:	1
ISSN:	1048-891X
Publisher:	Lippincott Williams & Wilkins
Date Published:	2010-01-01
Start Page:	2
End Page:	8
Language:	English
DOI:	10.1111/IGC.0b013e3181bf7d3f
PUBMED:	20130497
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-74249097167&partnerID=40&md5=cbd12c538a4d81f95c30c8cd7b41f2a3
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: IJGCE" - "Source: Scopus"