Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs Journal Article
| Authors: | Lussier, Y. A.; Khodarev, N. N.; Regan, K.; Corbin, K.; Li, H.; Ganai, S.; Khan, S. A.; Gnerlich, J.; Darga, T. E.; Fan, H.; Karpenko, O.; Paty, P. B.; Posner, M. C.; Chmura, S. J.; Hellman, S.; Ferguson, M. K.; Weichselbaum, R. R. |
| Article Title: | Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs |
| Abstract: | Rationale: Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed oligometastasis(es) characterized by limited progression has been proposed. Oligometastases are amenable to treatment by surgical resection or radiotherapy. Methods: We analyzed microRNA expression patterns from lung metastasis samples of patients with ≤5 initial metastases resected with curative intent. Results: Patients were stratified into subgroups based on their rate of metastatic progression. We prioritized microRNAs between patients with the highest and lowest rates of recurrence. We designated these as high rate of progression (HRP) and low rate of progression (LRP); the latter group included patients with no recurrences. The prioritized microRNAs distinguished HRP from LRP and were associated with rate of metastatic progression and survival in an independent validation dataset. Conclusion: Oligo- and poly- metastasis are distinct entities at the clinical and molecular level. © 2012 Lussier et al. |
| Journal Title: | PLoS ONE |
| Volume: | 7 |
| Issue: | 12 |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Date Published: | 2012-01-01 |
| Start Page: | e50141 |
| Language: | English |
| DOI: | 10.1371/journal.pone.0050141 |
| PROVIDER: | scopus |
| PMCID: | PMC3518475 |
| PUBMED: | 23251360 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 January 2013" - "Source: Scopus" |
