Endogenous human microRNAs that suppress breast cancer metastasis Journal Article


Authors: Tavazoie, S. F.; Alarcón, C.; Oskarsson, T.; Padua, D.; Wang, Q.; Bos, P. D.; Gerald, W. L.; Massague, J.
Article Title: Endogenous human microRNAs that suppress breast cancer metastasis
Abstract: A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as human breast cancer cells develop metastatic potential. Here we show that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer cells in vivo. Of these microRNAs, miR-126 restoration reduces overall tumour growth and proliferation, whereas miR-335 inhibits metastatic cell invasion. miR-335 regulates a set of genes whose collective expression in a large cohort of human tumours is associated with risk of distal metastasis. miR-335 suppresses metastasis and migration through targeting of the progenitor cell transcription factor SOX4 and extracellular matrix component tenascin C. Expression of miR-126 and miR-335 is lost in the majority of primary breast tumours from patients who relapse, and the loss of expression of either microRNA is associated with poor distal metastasis-free survival. miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer. ©2007 Nature Publishing Group.
Keywords: cancer survival; controlled study; protein expression; bone neoplasms; survival rate; human cell; cancer growth; nonhuman; bone metastasis; cell proliferation; animal cell; mouse; animal tissue; breast cancer; microrna; gene expression; protein targeting; lung neoplasms; animal experiment; animal model; recurrence; cancer cell culture; cell line, tumor; breast neoplasms; cancer invasion; rna; lung metastasis; gene expression regulation, neoplastic; bone; neoplasm metastasis; cell migration; cell movement; trans-activators; hominid; cell shape; micrornas; tumor; tenascin; high mobility group proteins; transcription factor sox4
Journal Title: Nature
Volume: 451
Issue: 7175
ISSN: 0028-0836
Publisher: Nature Publishing Group  
Date Published: 2008-01-10
Start Page: 147
End Page: 152
Language: English
DOI: 10.1038/nature06487
PUBMED: 18185580
PROVIDER: scopus
PMCID: PMC2782491
DOI/URL:
Notes: --- - "Cited By (since 1996): 411" - "Export Date: 17 November 2011" - "CODEN: NATUA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. William L Gerald
    370 Gerald
  2. Joan Massague
    291 Massague
  3. Paula Daniela Bos
    12 Bos
  4. David Padua
    4 Padua
  5. Qiongqing Wang
    7 Wang