MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer Journal Article
| Authors: | Png, K. J.; Yoshida, M.; Zhang, X. H. F.; Shu, W.; Lee, H.; Rimner, A.; Chan, T. A.; Comen, E.; Andrade, V. P.; Kim, S. W.; King, T. A.; Hudis, C. A.; Norton, L.; Hicks, J.; Massague, J.; Tavazoie, S. F. |
| Article Title: | MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer |
| Abstract: | Post-transcriptional regulators have emerged as robust effectors of metastasis and display deregulated expression through unknown mechanisms. Here, we reveal that the human microRNA-335 locus undergoes genetic deletion and epigenetic promoter hypermethylation in every metastatic derivative obtained from independent patients' malignant cell populations. Genetic deletion of miR-335 is a common event in human breast cancer, is enriched for in breast cancer metastases, and also correlates with ovarian cancer recurrence. We furthermore identify miR-335 as a robust inhibitor of tumor reinitiation. We thus implicate the miR-335 locus on 7q32.2 as the first selective metastasis suppressor and tumor initiation suppressor locus in human breast cancer. © 2011 by Cold Spring Harbor Laboratory Press. |
| Keywords: | metastasis; genetic; epigenetic; ovarian; mir-335; tumor intiation |
| Journal Title: | Genes and Development |
| Volume: | 25 |
| Issue: | 3 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2011-02-01 |
| Start Page: | 226 |
| End Page: | 231 |
| Language: | English |
| DOI: | 10.1101/gad.1974211 |
| PROVIDER: | scopus |
| PMCID: | PMC3034897 |
| PUBMED: | 21289068 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 March 2011" - "CODEN: GEDEE" - "Source: Scopus" |
