Magnetic Resonance Imaging (MRI) of hormone-induced breast changes in young premenopausal women Journal Article


Authors: Clendenen, T. V.; Kim, S.; Moy, L.; Wan, L.; Rusinek, H.; Stanczyk, F. Z.; Pike, M. C.; Zeleniuch-Jacquotte, A.
Article Title: Magnetic Resonance Imaging (MRI) of hormone-induced breast changes in young premenopausal women
Abstract: Objectives: We conducted a pilot study to identify whether MRI parameters are sensitive to hormone-induced changes in the breast during the natural menstrual cycle and whether changes could also be observed during an oral contraceptive (OC) cycle. Materials and Methods: The New York University Langone Medical Center Institutional Review Board approved this HIPAA-compliant prospective study. All participants provided written informed consent. Participants were aged 24-31 years.We measured several non-contrast breast MRI parameters during each week of a single menstrual cycle (among 9 women) and OC cycle (among 8 women). Hormones were measured to confirm ovulation and classify menstrual cycle phase among naturally cycling women and to monitor OC compliance among OC users. We investigated how the non-contrast MRI parameters of breast fibroglandular tissue (FGT), apparent diffusion coefficient (ADC), magnetization transfer ratio (MTR), and transverse relaxation time (T2) varied over the natural and the OC cycles. Results: We observed significant increases in MRI FGT% and ADC in FGT, and longer T2 in FGT in the luteal vs. follicular phase of the menstrual cycle. We did not observe any consistent pattern of change for any of the MRI parameters among women using OCs. Conclusions: MRI is sensitive to hormone-induced breast tissue changes during the menstrual cycle. Larger studies are needed to assess whether MRI is also sensitive to the effects of exogenous hormones, such as various OC formulations, on the breast tissue of young premenopausal women. © 2013 Elsevier Inc.
Keywords: breast mri; hormones; oral contraceptives; breast density; menstrual cycle; 3-point dixon; fibroglandular tissue; fibroglandular tissue percent
Journal Title: Magnetic Resonance Imaging
Volume: 31
Issue: 1
ISSN: 0730-725X
Publisher: Elsevier Science, Inc.  
Date Published: 2013-01-01
Start Page: 1
End Page: 9
Language: English
DOI: 10.1016/j.mri.2012.06.022
PROVIDER: scopus
PUBMED: 22898693
DOI/URL:
Notes: --- - "Export Date: 2 January 2013" - "CODEN: MRIMD" - "Source: Scopus"
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MSK Authors
  1. Malcolm Pike
    135 Pike