MRI background parenchymal enhancement, breast density and breast cancer risk factors: A cross-sectional study in pre- and post-menopausal women Journal Article

   

Authors:	Brooks, J. D.; Christensen, R. A. G.; Sung, J. S.; Pike, M. C.; Orlow, I.; Bernstein, J. L.; Morris, E. A.
Article Title:	MRI background parenchymal enhancement, breast density and breast cancer risk factors: A cross-sectional study in pre- and post-menopausal women
Abstract:	Breast tissue enhances on contrast MRI and is called background parenchymal enhancement (BPE). Having high BPE has been associated with an increased risk of breast cancer. We examined the relationship between BPE and the amount of fibroglandular tissue on MRI (MRI-FGT) and breast cancer risk factors. This was a cross-sectional study of 415 women without breast cancer undergoing contrast-enhanced breast MRI at Memorial Sloan Kettering Cancer Center. All women completed a questionnaire assessing exposures at the time of MRI. Prevalence ratios (PR) and 95% confidence intervals (CI) describing the relationship between breast cancer risk factors and BPE and MRI-FGT were generated using modified Poisson regression. In multivariable-adjusted models a positive association between body mass index (BMI) and BPE was observed, with a 5-unit increase in BMI associated with a 14% and 44% increase in prevalence of high BPE in pre- and post-menopausal women, respectively. Conversely, a strong inverse relationship between BMI and MRI-FGT was observed in both pre- (PR = 0.66, 95% CI 0.57, 0.76) and post-menopausal (PR = 0.66, 95% CI 0.56, 0.78) women. Use of preventive medication (e.g., tamoxifen) was associated with having low BPE, while no association was observed for MRI-FGT. BPE is an imaging marker available from standard contrast-enhanced MRI, that is influenced by endogenous and exogenous hormonal exposures in both pre- and post-menopausal women. © 2022, The Author(s).
Keywords:	adult; aged; major clinical study; cancer risk; nuclear magnetic resonance imaging; breast cancer; prevalence; aromatase inhibitor; cancer screening; risk factor; confidence interval; questionnaire; body mass; contrast enhancement; tamoxifen; interview; cross-sectional study; premenopause; alcohol consumption; menopause; postmenopause; oral contraceptive agent; raloxifene; breast magnetic resonance imaging; breast density; menstrual cycle; human; female; article; poisson regression; people by smoking status; prevalence ratio
Journal Title:	npj Breast Cancer
Volume:	8
ISSN:	2374-4677
Publisher:	Nature Publishing Group
Date Published:	2022-08-25
Start Page:	97
Language:	English
DOI:	10.1038/s41523-022-00458-2
PROVIDER:	scopus
PMCID:	PMC9411561
PUBMED:	36008488
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137057286&doi=10.1038%2fs41523-022-00458-2&partnerID=40&md5=d768b61175838d9ddae5042ed4333770
Notes:	Article -- Export Date: 3 October 2022 -- Source: Scopus

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