MEF promotes stemness in the pathogenesis of gliomas Journal Article
| Authors: | Bazzoli, E.; Pulvirenti, T.; Oberstadt, M. C.; Perna, F.; Wee, B.; Schultz, N.; Huse, J. T.; Fomchenko, E. I.; Voza, F.; Tabar, V.; Brennan, C. W.; De Angelis, L. M.; Nimer, S. D.; Holland, E. C.; Squatrito, M. |
| Article Title: | MEF promotes stemness in the pathogenesis of gliomas |
| Abstract: | High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation. © 2012 Elsevier Inc. |
| Journal Title: | Cell Stem Cell |
| Volume: | 11 |
| Issue: | 6 |
| ISSN: | 1934-5909 |
| Publisher: | Cell Press |
| Date Published: | 2012-12-07 |
| Start Page: | 836 |
| End Page: | 844 |
| Language: | English |
| DOI: | 10.1016/j.stem.2012.09.012 |
| PROVIDER: | scopus |
| PUBMED: | 23217424 |
| PMCID: | PMC3812924 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 January 2013" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work