The use of patient-reported outcomes (PRO) within comparative effectiveness research: Implications for clinical practice and health care policy Journal Article
| Authors: | Ahmed, S.; Berzon, R. A.; Revicki, D. A.; Lenderking, W. R.; Moinpour, C. M.; Basch, E.; Reeve, B. B.; Wu, A. W. |
| Article Title: | The use of patient-reported outcomes (PRO) within comparative effectiveness research: Implications for clinical practice and health care policy |
| Abstract: | BACKGROUND: The goal of comparative effectiveness research (CER) is to explain the differential benefits and harms of alternate methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care. To inform decision making, information from the patient's perspective that reflects outcomes that patients care about are needed and can be collected rigorously using appropriate patient-reported outcomes (PRO). It can be challenging to select the most appropriate PRO measure given the proliferation of such questionnaires over the past 20 years. OBJECTIVE: In this paper, we discuss the value of PROs within CER, types of measures that are likely to be useful in the CER context, PRO instrument selection, and key challenges associated with using PROs in CER. METHODS: We delineate important considerations for defining the CER context, selecting the appropriate measures, and for the analysis and interpretation of PRO data. Emerging changes that may facilitate CER using PROs as an outcome are also reviewed including implementation of electronic and personal health records, hospital and population-based registries, and the use of PROs in national monitoring initiatives. The potential benefits of linking the information derived from PRO endpoints in CER to decision making is also reviewed. CONCLUSIONS: The recommendations presented for incorporating PROs in CER are intended to provide a guide to researchers, clinicians, and policy makers to ensure that information derived from PROs is applicable and interpretable for a given CER context. In turn, CER will provide information that is necessary for clinicians, patients, and families to make informed care decisions. Copyright © 2012 by Lippincott Williams & Wilkins. |
| Keywords: | cancer chemotherapy; patient satisfaction; fluorouracil; unspecified side effect; research design; clinical practice; quality of life; breast cancer; lung non small cell cancer; health behavior; self report; outcome assessment (health care); cancer hormone therapy; health care policy; hospital; cost effectiveness analysis; health policy; questionnaire; depression; electronic medical record; population research; register; doctor patient relation; drug surveillance program; patient information; health status; folinic acid; comorbidity; patient-centered care; patient compliance; clinical decision making; asthma; corticosteroid; short form 36; navelbine; medical information system; fluoxetine; functional status; activities of daily living; caregiver burden; clinical assessment tool; randomized controlled trial (topic); budesonide; comparative effectiveness; desipramine; patient-reported outcome; comparative effectiveness research; patient reported outcome; imipramine; clinical care; fluticasone propionate plus salmeterol |
| Journal Title: | Medical Care |
| Volume: | 50 |
| Issue: | 12 |
| ISSN: | 0025-7079 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2012-12-01 |
| Start Page: | 1060 |
| End Page: | 1070 |
| Language: | English |
| DOI: | 10.1097/MLR.0b013e318268aaff |
| PROVIDER: | scopus |
| PUBMED: | 22922434 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 January 2013" - "CODEN: MDLCB" - "Source: Scopus" |
