The level of association between functional performance status measures and patient-reported outcomes in cancer patients: A systematic review Journal Article
| Authors: | Atkinson, T. M.; Andreotti, C. F.; Roberts, K. E.; Saracino, R. M.; Hernandez, M.; Basch, E. |
| Article Title: | The level of association between functional performance status measures and patient-reported outcomes in cancer patients: A systematic review |
| Abstract: | Purpose: The process of assessing patient symptoms and functionality using patient-reported outcomes (PROs) and functional performance status (FPS) is an essential aspect of patient-centered oncology research and care. However, PRO and FPS measures are often employed separately or inconsistently combined. Thus, the purpose of this study was to conduct a systematic review of the level of association between PRO and FPS measures to determine their differential or combined utility. Methods: A systematic search was conducted using five databases (1966 to February 2014) to identify studies that described an association between PRO and FPS. Studies were excluded if they were non-cancer specific, did not include adults aged 18 or older, or were review articles. Publications were selected for review by consensus among two authors, with a third author arbitrating as needed. Results: A total of 18 studies met inclusion criteria. FPS was primarily assessed by clinicians using the ECOG Performance Status or Karnofsky Performance Status measures. PROs were captured using a variety of measures, with numerous domains assessed (e.g., pain, fatigue, and general health status). Concordance between PROs and FPS measures was widely variable, falling in the low to moderate range (0.09–0.72). Conclusions: Despite consistency in the method of capture of PROs or FPS, domain capture varied considerably across reviewed studies. Irrespective of the method of capturing PROs or FPS, the quantified level of association between these two areas was moderate at best, providing evidence that FPS and PRO assessments offer unique information to assist clinicians in their decision-making. © 2015, Springer-Verlag Berlin Heidelberg. |
| Keywords: | review; cancer patient; pancreas cancer; outcome assessment; neoplasms; colorectal cancer; cancer immunotherapy; breast cancer; nonhodgkin lymphoma; health status; karnofsky performance status; systematic review; malignant neoplastic disease; mixed tumor; kidney cancer; short form 36; functional status; wellbeing; non small cell lung cancer; patient outcome assessment; biological response modifier; multicenter study (topic); patient reported outcome; emotional well being; human; priority journal; functional performance status; functional status assessment |
| Journal Title: | Supportive Care in Cancer |
| Volume: | 23 |
| Issue: | 12 |
| ISSN: | 0941-4355 |
| Publisher: | Springer Verlag |
| Date Published: | 2015-12-01 |
| Start Page: | 3645 |
| End Page: | 3652 |
| Language: | English |
| DOI: | 10.1007/s00520-015-2923-2 |
| PROVIDER: | scopus |
| PUBMED: | 26314706 |
| PMCID: | PMC4832926 |
| DOI/URL: | |
| Notes: | Export Date: 2 December 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work