The landscape of somatic copy-number alteration across human cancers Journal Article
| Authors: | Beroukhim, R.; Mermel, C. H.; Porter, D.; Wei, G.; Raychaudhuri, S.; Donovan, J.; Barretina, J.; Boehm, J. S.; Dobson, J.; Urashima, M.; McHenry, K. T.; Pinchback, R. M.; Ligon, A. H.; Cho, Y. J.; Haery, L.; Greulich, H.; Reich, M.; Winckler, W.; Lawrence, M. S.; Weir, B. A.; Tanaka, K. E.; Chiang, D. Y.; Bass, A. J.; Loo, A.; Hoffman, C.; Prensner, J.; Liefeld, T.; Gao, Q.; Yecies, D.; Signoretti, S.; Maher, E.; Kaye, F. J.; Sasaki, H.; Tepper, J. E.; Fletcher, J. A.; Tabernero, J.; Baselga, J.; Tsao, M. S.; Demichelis, F.; Rubin, M. A.; Jänne, P. A.; Daly, M. J.; Nucera, C.; Levine, R. L.; Ebert, B. L.; Gabrie, S.; Rustgi, A. K.; Antonescu, C. R.; Ladanyi, M.; Letai, A.; Garraway, L. A.; Loda, M.; Beer, D. G.; True, L. D.; Okamoto, A.; Pomeroy, S. L.; Singer, S.; Golub, T. R.; Lander, E. S.; Getz, G.; Sellers, W. R.; Meyerson, M. |
| Article Title: | The landscape of somatic copy-number alteration across human cancers |
| Abstract: | A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. Several gene families are enriched among these regions of focal SCNA, including the BCL2 family of apoptosis regulators and the NF-pathway. We show that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival. Finally, we demonstrate that a large majority of SCNAs identified in individual cancer types are present in several cancer types. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | signal transduction; survival; controlled study; human cell; genetic analysis; neoplasm; neoplasms; gene; cell survival; apoptosis; gene amplification; gene expression; immunoglobulin enhancer binding protein; bcl-x protein; cell line, tumor; histology; protein mcl 1; genomics; gene dosage; proto-oncogene proteins c-bcl-2; multigene family; dna copy number variations; landscape; frequency analysis; functional morphology; human behavior; resolution; bcl2 gene; bcl2l1 gene; somatic cell genetics; somatic copy number alteration |
| Journal Title: | Nature |
| Volume: | 463 |
| Issue: | 7283 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-02-18 |
| Start Page: | 899 |
| End Page: | 905 |
| Language: | English |
| DOI: | 10.1038/nature08822 |
| PUBMED: | 20164920 |
| PROVIDER: | scopus |
| PMCID: | PMC2826709 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 115" - "Export Date: 20 April 2011" - "CODEN: NATUA" - "Source: Scopus" |
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