The tert-Butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis Journal Article
| Authors: | Bauer, R. A.; Diblasi, C. M.; Tan, D. S. |
| Article Title: | The tert-Butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis |
| Abstract: | Figure presented A unified synthetic approach to diverse polycyclic scaffolds has been developed using transition-metal-mediated cycloaddition and cyclization reactions of enynes and diynes. The tert-butylsulfinamide group has been identified as a particularly versatile lynchpin in these reactions, with a reactivity profile uniquely suited for efficient, stereoselective substrate synthesis and downstream transformations. This approach provides 10 distinct, functionalized scaffold classes related to common core structures in alkaloid and terpenoid natural products. © 2010 American Chemical Society. |
| Keywords: | chemistry; magnetic resonance spectroscopy; nuclear magnetic resonance spectroscopy; cyclization; amides; amide; transition element; transition elements |
| Journal Title: | Organic Letters |
| Volume: | 12 |
| Issue: | 9 |
| ISSN: | 1523-7060 |
| Publisher: | American Chemical Society |
| Date Published: | 2010-05-07 |
| Start Page: | 2084 |
| End Page: | 2087 |
| Language: | English |
| DOI: | 10.1021/ol100574y |
| PUBMED: | 20356070 |
| PROVIDER: | scopus |
| PMCID: | PMC2869296 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "Source: Scopus" |
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