Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction Journal Article

   

Authors:	Lux, M. C.; Boby, M. L.; Brooks, J. L.; Tan, D. S.
Article Title:	Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction
Abstract:	Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords a variety of bicyclic ether scaffolds with complete diastereoselectivity for cis-ring fusion. © 2019 The Royal Society of Chemistry.
Journal Title:	Chemical Communications
Volume:	55
Issue:	49
ISSN:	1359-7345
Publisher:	Royal Society of Chemistry
Date Published:	2019-06-21
Start Page:	7013
End Page:	7016
Language:	English
DOI:	10.1039/c9cc03775f
PUBMED:	31147660
PROVIDER:	scopus
PMCID:	PMC6601619
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067277043&doi=10.1039%2fc9cc03775f&partnerID=40&md5=197824f7c1adac8aaa5ef7a595f7e4e3
Notes:	Article -- Source: Scopus

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