An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation Journal Article

   


Authors: Wang, P.; Aussedat, B.; Vohra, Y.; Danishefsky, S. J.
Article Title: An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation
Abstract: Like a Pro: A one-flask aspartylation/deprotection method, wherein long peptide fragments, bearing proximal pseudoproline functionality, are merged with complex glycan domains has been developed. Following aspartylation, acid-mediated global deprotection reveals the elaborated glycopeptide. The temporary pseudoproline functionality serves to suppress formation of aspartimide side products during solid-phase peptide synthesis and aspartylation. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords: glycopeptides; solid-phase synthesis; aspartimide; aspartylation; pseudoproline dipeptide
Journal Title: Angewandte Chemie - International Edition
Volume: 51
Issue: 46
ISSN: 1433-7851
Publisher: Wiley Blackwell  
Date Published: 2012-11-12
Start Page: 11571
End Page: 11575
Language: English
DOI: 10.1002/anie.201205038
PROVIDER: scopus
PMCID: PMC3500778
PUBMED: 23011954
DOI/URL:

http://release-www.scopus.com/inward/record.url?eid=2-s2.0-84868568294&partnerID=40&md5=ffde25ac5087227183766aa7113f7d50
Notes: --- - "Export Date: 3 December 2012" - "CODEN: ACIEF" - "Source: Scopus"
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MSK Authors
  1. Ping Wang
    19 Wang
  2. Baptiste Aussedat
    17 Aussedat
  3. Samuel J Danishefsky
    539 Danishefsky
  4. Yusufbhai Usmanbhai Vohra
    6 Vohra
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