FDG-PET SUVmax combined with IASLC/ATS/ERS histologic classification improves the prognostic stratification of patients with stage I lung adenocarcinoma Journal Article
| Authors: | Kadota, K.; Colovos, C.; Suzuki, K.; Rizk, N. P.; Dunphy, M. P. S.; Zabor, E. C.; Sima, C. S.; Yoshizawa, A.; Travis, W. D.; Rusch, V. W.; Adusumilli, P. S. |
| Article Title: | FDG-PET SUVmax combined with IASLC/ATS/ERS histologic classification improves the prognostic stratification of patients with stage I lung adenocarcinoma |
| Abstract: | Background. We investigated the association between the newly proposed International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/ European Respiratory Society (ERS) classification and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET), and whether the combination of these radiologic and pathologic factors can further prognostically stratify patients with stage I lung adenocarcinoma. Methods. We retrospectively evaluated 222 patients with pathologic stage I lung adenocarcinoma who underwent FDG-PET scanning before undergoing surgical resection between 1999 and 2005. Patients were classified by histologic grade according to the IASLC/ATS/ERS classification (low, intermediate, or high grade) and by maximum standard uptake value (SUVmax) (low<3.0, high ≥3.0). The cumulative incidence of recurrence (CIR) was used to estimate recurrence probabilities. Results. Patients with high-grade histology had higher risk of recurrence (5-year CIR, 29 % [n = 25]) than those with intermediate-grade (13 % [n = 181]) or low-grade (11 % [n = 16]) histology (p = 0.046). High SUVmax was associated with high-grade histology (P<0.001) and with increased risk of recurrence compared to low SUVmax (5-year CIR, 21 % [n = 113] vs. 8 % [n = 109]; p = 0.013). Among patients with intermediate-grade histology, those with high SUVmax had higher risk of recurrence than those with low SUVmax (5-year CIR, 19 % [n = 87] vs. 7 % [n = 94]; p = 0.033). SUVmax was associated with recurrence even after adjusting for pathologic stage (p = 0.037). Conclusions. SUVmax on FDG-PET correlates with the IASLC/ATS/ERS classification and can be used to stratify patients with intermediate-grade histology, the predominant histologic subtype, into two prognostic subsets. © Society of Surgical Oncology 2012. |
| Keywords: | adult; aged; major clinical study; histopathology; cancer recurrence; cancer staging; positron emission tomography; preoperative evaluation; retrospective study; lung adenocarcinoma; drug uptake; fluorodeoxyglucose f 18; cancer classification; cancer prognosis; american thoracic society classification; european respiratory society classification; international association for the study of lung cancer classification |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 19 |
| Issue: | 11 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2012-10-01 |
| Start Page: | 3598 |
| End Page: | 3605 |
| Language: | English |
| DOI: | 10.1245/s10434-012-2414-3 |
| PROVIDER: | scopus |
| PUBMED: | 22644511 |
| PMCID: | PMC4049004 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 December 2012" - "CODEN: ASONF" - "Source: Scopus" |
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