Enhancing radiotherapy through a greater understanding of homologous recombination Journal Article
| Authors: | Barker, C. A.; Powell, S. N. |
| Article Title: | Enhancing radiotherapy through a greater understanding of homologous recombination |
| Abstract: | Radiotherapy for the treatment of cancer can cause a wide range of cellular effects, the most biologically potent of which is the double-strand break in DNA. The process of repairing DNA double-strand breaks involves 1 of 2 major mechanisms: nonhomologous end joining or homologous recombination. In this review, we review the molecular mechanisms of homologous recombination, in particular as it relates to the repair of DNA damage from ionizing radiation. We also present specific situations in which homologous recombination may be dysfunctional in human cancers and how this functional abnormality can be recognized. We also discuss the therapeutic opportunities that can be exploited based on deficiencies in homologous recombination at various steps in the DNA repair pathway. Side-by-side with these potential therapeutic opportunities, we review the contemporary clinical trials in which strategies to exploit these defects in homologous recombination can be enhanced by the use of radiotherapy in conjunction with biologically targeted agents. We conclude that the field of radiation oncology has only scratched the surface of a potentially highly efficacious therapeutic strategy. © 2010 Elsevier Inc. |
| Keywords: | unclassified drug; acute granulocytic leukemia; histone deacetylase inhibitor; review; erlotinib; fluorouracil; gemcitabine; paclitaxel; cancer radiotherapy; temozolomide; neoplasms; dna damage; gene; homologous recombination; cell cycle; dna repair; imatinib; breast cancer; basal cell carcinoma; etoposide; lung cancer; dasatinib; bladder cancer; nonhodgkin lymphoma; dna; drug mechanism; head and neck cancer; radiation oncology; recombination, genetic; tumor cell; vorinostat; dna breaks, double-stranded; radiation, ionizing; tanespimycin; stomach cancer; mitomycin c; platinum derivative; thyroid cancer; meningioma; navelbine; rectum cancer; radiation-sensitizing agents; panobinostat; valproic acid; pci 24781 |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 20 |
| Issue: | 4 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-10-01 |
| Start Page: | 267 |
| End Page: | 273.e3 |
| Language: | English |
| DOI: | 10.1016/j.semradonc.2010.05.001 |
| PUBMED: | 20832019 |
| PROVIDER: | scopus |
| PMCID: | PMC4972489 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: SRONE" - "Source: Scopus" |
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