Cancer- and cancer treatment-associated cognitive change: An update on the state of the science Journal Article
| Authors: | Ahles, T. A.; Root, J. C.; Ryan, E. L. |
| Article Title: | Cancer- and cancer treatment-associated cognitive change: An update on the state of the science |
| Abstract: | Cognitive changes associated with cancer and cancer treatments have become an increasing concern. Using breast cancer as the prototype, we reviewed the research from neuropsychological, imaging, genetic, and animal studies that have examined pre- and post-treatment cognitive change. An impressive body of research supports the contention that a subgroup of patients is vulnerable to post-treatment cognitive problems. We also propose that models of aging may be a useful conceptual framework for guiding research in this area and suggest that a useful perspective may be viewing cognitive change in patients with cancer within the context of factors that influence the trajectory of normal aging. © 2012 by American Society of Clinical Oncology. |
| Keywords: | cancer chemotherapy; review; fluorouracil; nonhuman; side effect; cancer adjuvant therapy; cancer radiotherapy; radiotherapy, adjuvant; drug megadose; positron emission tomography; antineoplastic agent; neoplasms; animals; dna damage; breast cancer; models, biological; aromatase inhibitor; hemoglobin; breast neoplasms; cancer therapy; survivors; exemestane; cancer hormone therapy; goserelin; brain development; neuropsychological test; nuclear magnetic resonance spectroscopy; tamoxifen; cognition; aging; cognitive defect; cognitive rehabilitation; antioxidant; oxidative stress; diet therapy; anxiety; letrozole; mental concentration; motor performance; verbal memory; cognition disorders; hormone; attention; functional magnetic resonance imaging; anastrozole; kinesiotherapy; genotoxicity; learning; working memory; diffusion tensor imaging; apolipoprotein e; visual memory; psychomotor activity; depth perception; tamoxifen citrate; executive function; functional neuroimaging; catechol methyltransferase; chemoradiotherapy, adjuvant; abstract reasoning; fluency disorder; white matter lesion |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 30 |
| Issue: | 30 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2012-10-20 |
| Start Page: | 3675 |
| End Page: | 3686 |
| Language: | English |
| DOI: | 10.1200/jco.2012.43.0116 |
| PROVIDER: | scopus |
| PUBMED: | 23008308 |
| PMCID: | PMC3675678 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 3 December 2012" - "CODEN: JCOND" - "Source: Scopus" |
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