Reliable change in neuropsychological assessment of breast cancer survivors Journal Article
| Authors: | Andreotti, C.; Root, J. C.; Schagen, S. B.; McDonald, B. C.; Saykin, A. J.; Atkinson, T. M.; Li, Y.; Ahles, T. A. |
| Article Title: | Reliable change in neuropsychological assessment of breast cancer survivors |
| Abstract: | Background The purpose of this study was to enhance the current understanding and interpretation of longitudinal change on tests of neurocognitive function in individuals with cancer. Scores on standard neuropsychological instruments may be impacted by practice effects and other random forms of error. Methods The current study assessed the test-retest reliability of several tests and overarching cognitive domains comprising a neurocognitive battery typical of those used for research and clinical evaluation using relevant time frames. Practice effect-adjusted reliable change confidence intervals for test-retest difference scores based on a sample of patient-matched healthy controls are provided. Results By applying reliable change confidence intervals to scores from two samples of breast cancer patients at post-treatment follow-up assessment, meaningful levels of detectable change in cognitive functioning in breast cancer survivors were ascertained and indicate that standardized neuropsychological instruments may be subject to limitations in detection of subtle cognitive dysfunction over clinically relevant intervals, especially in patient samples with average to above average range baseline functioning. Conclusions These results are discussed in relation to reported prevalence of cognitive change in breast cancer patients along with recommendations for study designs that enhance detection of treatment effects. Copyright © 2015 John Wiley & Sons, Ltd. |
| Keywords: | adult; controlled study; aged; major clinical study; adjuvant therapy; cancer staging; breast cancer; cancer survivor; exemestane; survivorship; neuropsychological test; tamoxifen; cognition; cognitive defect; test retest reliability; neuropsychological assessment; verbal memory; working memory; randomized controlled trial (topic); visual memory; distractibility; executive function; human; female; article; cognitive function test |
| Journal Title: | Psycho-Oncology |
| Volume: | 25 |
| Issue: | 1 |
| ISSN: | 1057-9249 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2016-01-01 |
| Start Page: | 43 |
| End Page: | 50 |
| Language: | English |
| DOI: | 10.1002/pon.3799 |
| PROVIDER: | scopus |
| PMCID: | PMC4580503 |
| PUBMED: | 25808921 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 March 2016 -- Source: Scopus |
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