Seizures and epilepsy in cancer patients Journal Article
| Authors: | Avila, E. K.; Graber, J. |
| Article Title: | Seizures and epilepsy in cancer patients |
| Abstract: | Seizures in the general population may occur for a variety of reasons, including vascular, infectious, autoimmune, genetic, and traumatic causes. In the cancer population, seizures arise mainly as a result of an infiltrative neoplastic process in the brain. However, seizures as a result of cancer treatment, metabolic causes, or paraneoplastic diseases may occur in patients with systemic cancer, even in the absence of a cerebral lesion. The etiology of seizures in brain tumor patients includes primary cerebral neoplasms and metastatic brain lesions. The treatment for seizures in this population is multifaceted and involves surgery, radiation, chemotherapy, and antiepileptic drugs. All treatments have potential adverse effects, especially when combined. The treatment for brain tumor-associated seizures and epilepsy almost always is geared toward treating the tumor, but subsequent treatment of seizures often is necessary. A pragmatic approach to this problem is essential to mitigate potential complications from treatment. © 2010 Springer Science+Business Media, LLC. |
| Keywords: | cancer survival; cancer surgery; prednisone; clinical trial; disease course; drowsiness; drug tolerability; fatigue; review; cisplatin; doxorubicin; cancer combination chemotherapy; drug efficacy; drug withdrawal; side effect; unspecified side effect; paclitaxel; adjuvant therapy; cancer patient; cancer radiotherapy; methotrexate; temozolomide; brain tumor; glioma; brain neoplasms; antineoplastic agent; cancer grading; disease association; unindexed drug; anemia; bone marrow suppression; etoposide; gastrointestinal symptom; nausea; vomiting; incidence; vincristine; procarbazine; thiotepa; vinblastine; lymphocytopenia; insomnia; depression; drug antagonism; sexual dysfunction; etiracetam; oxcarbazepine; phenobarbital; topiramate; add on therapy; cerebrovascular disease; brain metastasis; disease free interval; nitrosourea; cognitive defect; seizure; headache; drug absorption; somnolence; behavior disorder; anticonvulsive agent; disease control; epilepsy; irritability; neuropathic pain; astrocytoma; inappropriate vasopressin secretion; drug protein binding; phenytoin; teniposide; anticonvulsants; mood disorder; valproic acid; carbamazepine; gabapentin; electroencephalography; antiepileptic drugs; non convulsive status epilepticus; seizures; 9 aminocamptothecin; harkoseride; lamotrigine; nitrosourea derivative; pregabalin; zonisamide; anticonvulsant therapy; central nervous system infection; coordination disorder; epileptic state; leukocyte adherence inhibition; mental instability; nephrolithiasis; shoulder hand syndrome; thrombocyte aggregation inhibition; traumatic brain injury |
| Journal Title: | Current Neurology and Neuroscience Reports |
| Volume: | 10 |
| Issue: | 1 |
| ISSN: | 1528-4042 |
| Publisher: | Springer |
| Date Published: | 2010-01-01 |
| Start Page: | 60 |
| End Page: | 67 |
| Language: | English |
| DOI: | 10.1007/s11910-009-0080-z |
| PUBMED: | 20425228 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: CNNRB" - "Source: Scopus" |
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