Cerebral herniation in patients receiving cisplatin Journal Article


Authors: Walker, R. W.; Cairncross, J. G.; Posner, J. B.
Article Title: Cerebral herniation in patients receiving cisplatin
Abstract: 5 Patients with intracranial mass lesions are described who experienced cerebral herniation and coma following intravenous cisplatin therapy. Although the pathogenesis of the acute cerebral swelling is unknown, it is most likely multifactorial. Possible contributing factors include pre-existing cerebral edema, acute hypo-osmolality with fluid shifts into an already swollen brain, seizures and possible direct neurotoxicity of cisplatin. © 1988 Kluwer Academic Publishers.
Keywords: adult; child; clinical article; case report; cisplatin; brain neoplasms; dexamethasone; carmustine; medulloblastoma; seizure; intravenous drug administration; brain edema; brain hernia; computer analysis; middle age; herniation; encephalocele; human; male; female; support, non-u.s. gov't; cns toxicity
Journal Title: Journal of Neuro-Oncology
Volume: 6
Issue: 1
ISSN: 0167-594X
Publisher: Springer  
Date Published: 1988-05-01
Start Page: 61
End Page: 65
Language: English
DOI: 10.1007/bf00163542
PUBMED: 3397766
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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  1. Jerome B Posner
    211 Posner
  2. Russell W. Walker
    38 Walker