Cytokines and chemokines in stroke Book Section
| Authors: | Ballesteros, I.; Cuartero, M. I.; Pradillo, J. M.; Moro, M. A.; Lizasoain, I. |
| Article/Chapter Title: | Cytokines and chemokines in stroke |
| Abstract: | Cytokines and chemokines are key molecules that mediate the brain innate immune response after stroke. Cytokines activate immune, glial, and endothelial cells and trigger the initiation of brain acute response to the ischemic insult. This leads to neuroinflammation and cell death. In addition, chemokines are in charge of attracting leukocytes to the ischemic tissue, a pull factor that amplifies the initial inflammatory response. During the chronic phase of inflammation, cytokines and chemokines also play important roles in tissue repair and neurogenesis. These pleiotropic actions, as well as their systemic and local effects, have potential translational possibilities for the treatment of patients with stroke. This communication network is tightly regulated in time and space and its role seems to vary during the acute and chronic phase of cerebral ischemia showing deleterious and beneficial actions. This complex system requires further research efforts to exploit its potential translational benefits. © 2017 Elsevier Inc. All rights reserved. |
| Keywords: | angiogenesis; cytokine; chemokine; ischemia; stroke; innate immunity; neurogenesis; neuroinflammation; neurorepair |
| Book Title: | Primer on Cerebrovascular Diseases. 2nd ed |
| ISBN: | 978-0-12-803058-5 |
| Publisher: | Academic Press, Elsevier Inc |
| Publication Place: | London, UK |
| Date Published: | 2017-01-01 |
| Start Page: | 280 |
| End Page: | 284 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-803058-5.00058-8 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 58 -- Export Date: 2 October 2017 -- Source: Scopus |
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