Bringing the genomic landscape of small-cell lung cancer into focus Journal Article

  


Authors: Pietanza, M. C.; Ladanyi, M.
Article Title: Bringing the genomic landscape of small-cell lung cancer into focus
Abstract: Genomic characterization efforts in small-cell lung cancer have been complicated by the paucity of high-quality surgical resection specimens for this aggressive lung cancer subtype that is usually diagnosed at unresectable stages in small biopsies or cytology specimens. Now, two papers report genomic analyses of small-cell lung cancer, highlighting subsets of tumors driven by amplification of FGFR1, SOX2 or MYC family members or by a MYCL1 fusion oncogene, among many other recurrent alterations. © 2012 Nature America, Inc. All rights reserved.
Keywords: cancer survival; gene mutation; cisplatin; erlotinib; cancer combination chemotherapy; cancer growth; topotecan; recurrent cancer; antineoplastic agent; cytology; animals; carboplatin; quality of life; gene amplification; etoposide; lung non small cell cancer; lung neoplasms; tumor biopsy; mutational analysis; phosphatidylinositol 3 kinase; genome analysis; oncogene; lung adenocarcinoma; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; gefitinib; fusion gene; genome; inoperable cancer; cancer tissue; lung squamous cell carcinoma; oncogene c myc; lung biopsy; transcription factor sox2; soxb1 transcription factors; genetic marker; fibroblast growth factor receptor 1; genome, human; genetic heterogeneity; small cell lung carcinoma; crizotinib; fgfr1 gene; sox2 gene; mycl1 gene; rlf mycl1 fusion gene
Journal Title: Nature Genetics
Volume: 44
Issue: 10
ISSN: 1061-4036
Publisher: Nature Publishing Group  
Date Published: 2012-10-01
Start Page: 1074
End Page: 1075
Language: English
DOI: 10.1038/ng.2415
PROVIDER: scopus
PUBMED: 23011222
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84866857282&partnerID=40&md5=827c9b15fe9d2fb55d51ea426c1c8b1a
Notes: --- - "Export Date: 2 November 2012" - "CODEN: NGENE" - "Source: Scopus"
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MSK Authors
  1. Maria C Pietanza
    122 Pietanza
  2. Marc Ladanyi
    1333 Ladanyi
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