Impact of obesity and body fat distribution on survival after pancreaticoduodenectomy for pancreatic adenocarcinoma Journal Article


Authors: Gaujoux, S.; Torres, J.; Olson, S.; Winston, C.; Gonen, M.; Brennan, M. F.; Klimstra, D. S.; D'Angelica, M.; DeMatteo, R.; Fong, Y.; House, M.; Jarnagin, W.; Kurtz, R. C.; Allen, P. J.
Article Title: Impact of obesity and body fat distribution on survival after pancreaticoduodenectomy for pancreatic adenocarcinoma
Abstract: Background: Epidemiologic studies have reported a positive correlation between body mass index (BMI) and pancreatic cancer risk, but clinical relevance of obesity and/or body fat distribution on tumor characteristics and cancer-related outcome remain controversial. We sought to assess the influence of obesity and body fat distribution on pathologic characteristics and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Methods: Demographic and biometric data were collected on 328 patients undergoing pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. In a subset of patients, pancreatic fatty infiltration and fibrosis were assessed pathologically, and visceral fat area (VFA) was evaluated. Influence of BMI and body fat distribution on tumor characteristics and survival were evaluated. Results: A significant positive correlation between BMI and VFA was observed, with a wide range of VFA value within each BMI class. According to BMI or VFA distribution, there were no significant differences in patient characteristics, intraoperative or perioperative outcome, or pathologic characteristics, with the exception of significantly higher blood loss in patients with an increased body weight or VFA. Unadjusted overall and disease-free survival between BMI class and VFA quartile were not significantly different. Conclusions: In this study, obesity and body fat distribution were not correlated with specific tumor characteristics or cancer-related outcome. © Society of Surgical Oncology 2012.
Journal Title: Annals of Surgical Oncology
Volume: 19
Issue: 9
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2012-09-01
Start Page: 2908
End Page: 2916
Language: English
DOI: 10.1245/s10434-012-2301-y
PROVIDER: scopus
PUBMED: 22411205
DOI/URL:
Notes: --- - "Export Date: 2 November 2012" - "CODEN: ASONF" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Murray F Brennan
    750 Brennan
  2. Ronald P Dematteo
    591 Dematteo
  3. Sara H Olson
    207 Olson
  4. Mithat Gonen
    692 Gonen
  5. Michael Garrett House
    8 House
  6. David S Klimstra
    835 Klimstra
  7. Peter Allen
    433 Allen
  8. William R Jarnagin
    576 Jarnagin
  9. Yuman Fong
    734 Fong
  10. Corinne B Winston
    26 Winston
  11. Sebastien Gaujoux
    10 Gaujoux
  12. Robert C Kurtz
    130 Kurtz
  13. John Paul Torres
    6 Torres