Association between visceral and subcutaneous adiposity and clinicopathological outcomes in non-metastatic clear cell renal cell carcinoma Journal Article


Authors: Mano, R.; Hakimi, A. A.; Zabor, E. C.; Bury, M. A.; Donati, O. F.; Karlo, C. A.; Bazzi, W. M.; Furberg, H.; Russo, P.
Article Title: Association between visceral and subcutaneous adiposity and clinicopathological outcomes in non-metastatic clear cell renal cell carcinoma
Abstract: Methods: The medical records of 220 surgically treated ccRCC patients with documented preoperative body mass index (BMI) and computed tomography (CT) scans were retrospectively reviewed. Nineteen patients with stage IV disease were excluded. Visceral (VFA) and subcutaneous fat area (SFA) were computed from preoperative CT scans. Correlations between obesity measures were assessed with Pearson correlation. Associations between obesity measures and pathologic features were evaluated using logistic regression models adjusted for sex. Overall survival (OS) probabilities were estimated using Cox regression analysis. The log-rank test was used for group comparisons. Introduction: Visceral adiposity has been inconsistently associated with clinicopathologic features and outcomes of clear cell renal cell carcinoma (ccRCC); however, most studies were conducted in non-Western populations. We evaluated the associations between visceral and subcutaneous adiposity and clinicopathological characteristics of non-metastatic ccRCC patients in a Western population. Results: The study cohort comprised 150 men and 51 women. Women had higher SFA (p = 0.01) but lower VFA (p < 0.001) than men. BMI was highly correlated with SFA (r = 0.804) and moderately correlated with VFA (r = 0.542). SFA and VFA were weakly correlated (r = 0.367). An increased BMI was associated with a better OS (p = 0.028). When adjusting for sex, neither SFA nor VFA was significantly associated with tumour grade, stage, or OS. Conclusions: Consistent with prior reports, our study suggests that increased BMI is associated with a better OS for patient with nonmetastatic ccRCC. Despite the high correlation between SFA and BMI, neither SFA nor VFA were significantly associated with tumour stage, grade, or OS in the current study; however, further studies in larger cohorts are required to validate this finding.
Journal Title: CUAJ-Canadian Urological Association Journal
Volume: 8
Issue: 9-10
ISSN: 1911-6470
Publisher: Canadian Urological Association  
Date Published: 2014-09-01
Start Page: E675
End Page: E680
Language: English
DOI: 10.5489/cuaj.1979
PROVIDER: scopus
PMCID: PMC4216298
PUBMED: 25408806
DOI/URL:
Notes: Export Date: 2 February 2015 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Paul Russo
    443 Russo
  2. Emily Craig Zabor
    119 Zabor
  3. Christoph Alexander Karlo
    17 Karlo
  4. Olivio Fabrizio Manolo Donati
    16 Donati
  5. Abraham Ari Hakimi
    127 Hakimi
  6. Wassim Mousa Bazzi
    14 Bazzi
  7. Roy Mano
    20 Mano
  8. Marta Anna Bury
    1 Bury