Previous lung diseases and lung cancer risk: A pooled analysis from the international lung cancer consortium Journal Article


Authors: Brenner, D. R.; Boffetta, P.; Duell, E. J.; Bickeböller, H.; Rosenberger, A.; McCormack, V.; Muscat, J. E.; Yang, P.; Wichmann, H. E.; Brueske-Hohlfeld, I.; Schwartz, A. G.; Cote, M. L.; Tjonneland, A.; Friis, S.; Le Marchand, L.; Zhang, Z. F.; Morgenstern, H.; Szeszenia-Dabrowska, N.; Lissowska, J.; Zaridze, D.; Rudnai, P.; Fabianova, E.; Foretova, L.; Janout, V.; Bencko, V.; Schejbalova, M.; Brennan, P.; Mates, I. N.; Lazarus, P.; Field, J. K.; Raji, O.; McLaughlin, J. R.; Liu, G.; Wiencke, J.; Neri, M.; Ugolini, D.; Andrew, A. S.; Lan, Q.; Hu, W.; Orlow, I.; Park, B. J.; Hung, R. J.
Article Title: Previous lung diseases and lung cancer risk: A pooled analysis from the international lung cancer consortium
Abstract: To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (19842011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95 confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95 CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk 1.48, 95 CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk 1.57, 95 CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk. © 2012 The Author.
Keywords: disease course; review; cancer risk; disease association; logistic models; lung neoplasms; proportional hazards models; risk factors; lung cancer; smoking; histology; age; self report; risk; pneumonia; europe; systematic review; public health; sex difference; health risk; tobacco; nicotiana tabacum; logistic regression analysis; meta analysis; tuberculosis; north america; bronchitis; meta-analysis; chronic; medical history; lung diseases; emphysema; chronic bronchitis; tuberculosis, pulmonary; chronic obstructive; pulmonary disease; bronchitis, chronic; pulmonary emphysema
Journal Title: American Journal of Epidemiology
Volume: 176
Issue: 7
ISSN: 0002-9262
Publisher: Oxford University Press  
Date Published: 2012-10-01
Start Page: 573
End Page: 585
Language: English
DOI: 10.1093/aje/kws151
PROVIDER: scopus
PUBMED: 22986146
PMCID: PMC3530374
DOI/URL:
Notes: --- - "Export Date: 2 November 2012" - "CODEN: AJEPA" - "Source: Scopus"
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MSK Authors
  1. Irene Orlow
    192 Orlow
  2. Bernard J Park
    156 Park