Glucocorticoid-induced tumor necrosis factor receptor is a p21 Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis Journal Article

  

Authors:	Wang, J.; Devgan, V.; Corrado, M.; Prabhu, N. S.; El-Deiry, W. S.; Riccardi, C.; Pandolfi, P. P.; Missero, C.; Dotto, G. P.
Article Title:	Glucocorticoid-induced tumor necrosis factor receptor is a p21 Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis
Abstract:	Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a member of the tumor necrosis factor receptor superfamily, is expressed in T lymphocytes, and exerts an anti-apoptotic function in these cells. We reported that GITR is also highly expressed in the skin, specifically in keratinocytes, and that it is under negative transcriptional control of p21Cip1/WAF1, independently from the cell cycle. Although GITR expression is higher in p21-deficient keratinocytes and skin, it is down-modulated with differentiation and in response to UVB. The combined analysis of keratinocytes with increased GITR expression versus normal keratinocytes and skin of mice with a disruption of the GITR gene indicates that this protein protects keratinocytes from UVB-induced apoptosis both in vitro and in vivo. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc.
Keywords:	controlled study; protein expression; unclassified drug; gene deletion; nonhuman; ultraviolet radiation; t lymphocyte; proteins; animal cell; mouse; cytology; metabolism; animals; mice; gene; cells, cultured; cell cycle; apoptosis; genes; epidermis; protein targeting; cell differentiation; transcription, genetic; in vitro study; keratinocyte; animalia; skin; transcription regulation; tumors; gene disruption; down regulation; tumor necrosis factor receptor; cyclin-dependent kinase inhibitor p21; protein family; ultraviolet b radiation; ultraviolet rays; glucocorticoid induced tumor necrosis factor receptor; biochemistry; cell protection; keratinocytes; neurology; t lymphocytes; ultraviolet irradiation; glucocorticoids; receptors, tumor necrosis factor; receptors, nerve growth factor; cyclin dependent kinase inhibitor 1; glucocorticoid-induced tumor necrosis factor receptors (gitr); gitr gene
Journal Title:	Journal of Biological Chemistry
Volume:	280
Issue:	45
ISSN:	0021-9258
Publisher:	American Society for Biochemistry and Molecular Biology
Date Published:	2005-11-11
Start Page:	37725
End Page:	37731
Language:	English
DOI:	10.1074/jbc.M507976200
PUBMED:	16155000
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-27844470637&partnerID=40&md5=ef72baf8ab1b47842a79aa2104661fdb
Notes:	--- - "Cited By (since 1996): 20" - "Export Date: 24 October 2012" - "CODEN: JBCHA" - "Source: Scopus"

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