Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration Journal Article
| Authors: | Ulbricht, C.; Basch, E.; Boon, H.; Ernst, E.; Hammerness, P.; Sollars, D.; Tsourounis, C.; Woods, J.; Bent, S. |
| Article Title: | Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration |
| Abstract: | This systematic review discusses the proposed uses, dosing parameters adverse effects, toxicology, interactions and mechanism of action of kava. The widespread concern regarding the potential hepatotoxicity of kava is discussed. A recommendation is made to consolidate and analyse available reports and to continue postmarket surveillance in an international repository to prevent duplicates and promote collection of thorough details at the time of each report so that any association with kava is clearly defined. © 2005 Ashley Publications Ltd. |
| Keywords: | unclassified drug; clinical trial; drowsiness; fatigue; review; drug potentiation; liver cirrhosis; nonhuman; skin toxicity; skin manifestation; methotrexate; neurotoxicity; antineoplastic agent; drug eruption; liver toxicity; gastrointestinal symptom; nausea; thrombocytopenia; haloperidol; risperidone; extrapyramidal symptom; furosemide; dose-response relationship, drug; tyrosine; drug hypersensitivity; dyspnea; lymphocytopenia; drug induced headache; hypoalbuminemia; drug research; drug surveillance program; data collection; polycythemia; drug mechanism; systematic review; paracetamol; alcohol; muscle weakness; erythema; toxicity testing; benzodiazepine derivative; neuroleptic agent; anxiety disorder; safety; plant extract; plant medicinal product; plant preparations; herbaceous agent; herb; ketoconazole; drug half life; drug dose regimen; alprazolam; lethargy; postmarketing surveillance; metoclopramide; tremor; captopril; dipeptidyl carboxypeptidase inhibitor; ramipril; visual disorder; droperidol; fluoxetine; paroxetine; sertraline; disease exacerbation; visual impairment; meta analysis; dopamine; drug interactions; diuretic agent; resin; tachycardia; phenylalanine; antithrombocytic agent; cytochrome p450; epigastric pain; eye irritation; ecg abnormality; muscle cramp; oxycodone; drug indication; quinapril; diaphoresis; cimetidine; lactone derivative; serotonin uptake inhibitor; herbal medicine; medicinal plant; fluvoxamine; hepatotoxicity; anabolic agent; pulmonary hypertension; liver necrosis; sedative agent; contact dermatitis; sudden death; disorientation; rhabdomyolysis; s adenosylmethionine; uterus disease; anesthetic agent; buspirone; yohimbine; amiodarone; alkaloid; parkinsonism; dextropropoxyphene; pyrone derivative; anxiolytic agent; kava; central depressant agent; dyskinesia; pyridoxine; ephedra extract; hypericum perforatum extract; diazepam; dopamine receptor blocking agent; melatonin; lisinopril; ginseng extract; barbituric acid derivative; echinacea extract; torticollis; hypertensive crisis; garlic extract; kava extract; valerian; chromium; ginkgo biloba extract; clobazam; fenugreek; monoamine oxidase inhibitor; terazosin; urtica dioica; dopamine receptor stimulating agent; choreoathetosis; toxic hepatitis; anxiolytic; dihydrokawain; dihydromethysticin; kawain; methystici; piper methysticum; yangona; 5 hydroxytryptophan; acetazolamide; amiloride; benazepril; calamus extract; calendula extract; capsicum extract; carrot extract; catnip; catnip extract; celery extract; cornus extract; couch grass extract; elecampane extract; eschscholtzia extract; fenugreek extract; flavanoid; gotu kola extract; guarana extract; kavalactone; leitan; lemon balm extract; lettuce extract; li 150; matricaria extract; methysticin; opipramol; phenelzine; pipermethystine; prasterone; primrose oil; sage extract; sassafras extract; scullcap extract; shepherd purse extract; tranylcypromine; tyramine; urtica dioica extract; withania extract; yangonin; yerba mansa extract; apathy; carrot; celery; cornus; couch grass; drug milk level; elecampane; eschscholtzia; gotu kola; guarana; hops; hydrastis; hydrastis extract; lemon balm; lettuce; matricaria; meninx disorder; oculogyric crisis; pepper; sage; sassafras; scullcap; sheperd purse; withania; yerba |
| Journal Title: | Expert Opinion on Drug Safety |
| Volume: | 4 |
| Issue: | 4 |
| ISSN: | 1474-0338 |
| Publisher: | Informa Healthcare |
| Date Published: | 2005-07-01 |
| Start Page: | 779 |
| End Page: | 794 |
| Language: | English |
| DOI: | 10.1517/14740338.4.4.779 |
| PUBMED: | 16011454 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 14" - "Export Date: 24 October 2012" - "CODEN: EODSA" - "Source: Scopus" |
