TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro Journal Article

   


Authors: Tremblay, C. L.; Giguel, F.; Guan, Y.; Chou, T. C.; Takashima, K.; Hirsch, M. S.
Article Title: TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro
Abstract: TAK-220 is a CCR5 antagonist, part of the new class of anti-human immunodeficiency virus type 1 (anti-HIV-1) entry inhibitors. We evaluated the anti-HIV-1 interactions between TAK-220 and various anti-retrovirals in vitro. Synergy was observed with all drugs at the 90 and 95% inhibitory concentrations. The favorable drug interactions observed suggest that further clinical evaluation is warranted. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Keywords: controlled study; unclassified drug; human cell; drug activity; drug potentiation; nonhuman; enzyme inhibition; in vitro study; drug receptor binding; drug synergism; leukocytes, mononuclear; antiretrovirus agent; anti-hiv agents; hiv infections; peripheral blood mononuclear cell; human immunodeficiency virus 1; hiv-1; zidovudine; lamivudine; indinavir; minimum inhibitory concentration; anti human immunodeficiency virus agent; chemokine receptor ccr5; efavirenz; receptors, ccr5; enfuvirtide; 1 acetyl n [3 [4 (4 carbamoylbenzyl) 1 piperidinyl]propyl] n (3 chloro 4 methylphenyl) 4 piperidinecarboxamide; reverse transcriptase inhibitors
Journal Title: Antimicrobial Agents and Chemotherapy
Volume: 49
Issue: 8
ISSN: 0066-4804
Publisher: American Society for Microbiology  
Date Published: 2005-08-01
Start Page: 3483
End Page: 3485
Language: English
DOI: 10.1128/aac.49.8.3483-3485.2005
PUBMED: 16048964
PROVIDER: scopus
PMCID: PMC1196290
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-23044484979&partnerID=40&md5=4f10d4d275e97a94600a85b12b629f41
Notes: --- - "Cited By (since 1996): 21" - "Export Date: 24 October 2012" - "CODEN: AMACC" - "Source: Scopus"
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MSK Authors
  1. Yongbiao Guan
    11 Guan
  2. Ting-Chao Chou
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