Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene Journal Article

   


Authors: Timmer, J. R.; Mak, T. W.; Manova, K.; Anderson, K. V.; Niswander, L.
Article Title: Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene
Abstract: Adhesive properties of cells undergoing morphogenetic rearrangements can be regulated either at the cellular level or by altering the environment in which rearrangements occur. Here, we describe the identification of a mutation (myF11) in the mouse extracellular matrix component Frem2, and provide evidence that suggests Frem2 expression creates an environment conducive to morphogenetic events. Loss of Frem2 function results in defects in developmental events associated with morphogenetic rearrangements of the vasculature and of tissues arising from all germ layers. The Frem2 transcript is restricted both spatially and temporally and appears in advance of cell rearrangement events. Thus, expression of Frem2 may dynamically alter the extracellular matrix to provide a substrate for cell migration and rearrangements during embryogenesis. © 2005 by The National Academy of Sciences of the USA.
Keywords: controlled study; protein expression; unclassified drug; gene mutation; mutation; nonhuman; protein function; animal cell; mouse; phenotype; animals; mice; gene product; morphogenesis; genetic transcription; extracellular matrix; gene expression regulation, developmental; extremities; cell migration; cell aggregation; cell adhesion; neural tube defect; germ layer; hemorrhage; extracellular matrix proteins; medulla oblongata; calxβ; frem; protein frem2
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 102
Issue: 33
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 2005-08-16
Start Page: 11746
End Page: 11750
Language: English
DOI: 10.1073/pnas.0505404102
PUBMED: 16087869
PROVIDER: scopus
PMCID: PMC1183448
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-23844445146&partnerID=40&md5=ad76ac9e35f909afa58049fd9ab345d9
Notes: --- - "Cited By (since 1996): 24" - "Export Date: 24 October 2012" - "CODEN: PNASA" - "Source: Scopus"
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MSK Authors
  1. Lee A Niswander
    72 Niswander
  2. John Timmer
    8 Timmer
  3. Kathryn Anderson
    148 Anderson
  4. Katia O Manova-Todorova
    161 Manova-Todorova
  5. Tracy Mak
    1 Mak
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