Macrolides: A treatment alternative for bronchiolitis obliterans organizing pneumonia? Journal Article

  


Authors: Stover, D. E.; Mangino, D.
Article Title: Macrolides: A treatment alternative for bronchiolitis obliterans organizing pneumonia?
Abstract: Some macrolides have been found to exert anti-inflammatory effects. Lung diseases such as asthma, panbronchiolitis, cystic fibrosis, and bronchiectasis are thought to respond to the immunomodulatory properties of macrolides. We report three cases of idiopathic bronchiolitis obliterans organizing pneumonia, now called cryptogenic organizing pneumonia, and three cases of radiation-related bronchiolitis obliterans organizing pneumonia that responded to macrolide therapy. An explanation of why macrolides may have anti-inflammatory effects in patients with these syndromes is discussed. These cases help to reinforce accumulating data that macrolides are beneficial as anti-inflammatory agents and organizing pneumonia may be another pulmonary disease that can benefit from such therapy.
Keywords: adult; clinical article; human tissue; treatment outcome; aged; review; side effect; treatment; radiotherapy; tomography, x-ray computed; rash; anti-bacterial agents; cystic fibrosis; immunomodulation; antiinflammatory activity; asthma; clarithromycin; corticosteroid; macrolide; cough; antiinflammatory agent; macrolides; bronchiolitis; idiopathic disease; avascular necrosis; bronchiectasis; organizing pneumonia; bronchiolitis obliterans; bronchiolitis obliterans organizing pneumonia; cryptogenic organizing pneumonia
Journal Title: Chest
Volume: 128
Issue: 5
ISSN: 0012-3692
Publisher: American College of Chest Physicians  
Date Published: 2005-11-01
Start Page: 3611
End Page: 3617
Language: English
DOI: 10.1378/chest.128.5.3611
PUBMED: 16304320
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-28144460259&partnerID=40&md5=168e1242e24c176c26b29e505008a57a
Notes: --- - "Cited By (since 1996): 32" - "Export Date: 24 October 2012" - "CODEN: CHETB" - "Source: Scopus"
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MSK Authors
  1. Debra A Mangino
    17 Mangino
  2. Diane E Stover-Pepe
    109 Stover-Pepe
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